Byssinosis: airway responses in textile dust exposure.

Details

• Personal Author:
  Bouhuys A ; Zuskin E
• Description:
  Hemp dust and hemp dust extracts were tested in healthy subjects pretreated with propranolol (318989), ascorbic-acid, and disodium- cromoglycate (DSCG), in order to obtain more information on the mechanism of textile dust effects. The inhalation of textile dusts causes bronchoconstriction. The airway responses to these dusts are potentiated by propranolol and inhibited by an antihistamine and by ascorbic-acid. Administration of disodium-cromoglycate by spinhaler 30 minutes prior to challenge with hemp dust or hemp dust extract protected some subjects against the airway constrictor effect, mostly those with a large acute reduction in flow rates. Textile dust extracts contain a histamine releasing agent, which explains their airway constrictor effect. This agent is a highly water- soluble, heat-stable, low-molecular-weight compound which has not yet been chemically identified. In the prevention and control of byssinosis, the administration of drugs such as ascorbic-acid or disodium-cromoglycate should be considered in addition to engineering methods. [Description provided by NIOSH]
• Subjects:
  Dust Occupational Health Preventive Medicine Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Antihistamines Control-measures Dust-inhalation JOCMA7 Medical-treatment NIOSH-Grant NIOSH-Publication Organic-dusts Pharmacology Preventive-medicine Pulmonary-system-disorders Respiratory-functions Respiratory-system-disorders Vitamins

  More +
• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  357-359
• Volume:
  17
• Issue:
  6
• NIOSHTIC Number:
  nn:00048392
• Citation:
  J Occup Med 1975 Jun; 17(6):357-359
• Contact Point Address:
  John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
• CAS Registry Number:
  Propranolol hydrochloride (CAS RN 318-98-9)
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  John B Pierce Fdn of Conn Inc, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Journal of Occupational Medicine
• End Date:
  19770630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:81cf1d172ae8c6a41db3c2c256f12607f6929b2b374622cd1e55cf5ed87082dc83217b4e383b0da03de1608b6b7dcbf365a2564d560dbf1896b1c8938c980e28
• Download URL:
  https://stacks.cdc.gov/view/cdc/184046/cdc_184046_DS1.pdf
• File Type:
  [PDF - 274.41 KB ]