Neurotoxicity produced by intracranial administration of methylmercury in rats.

Details

• Personal Author:
  Murphy SD ; Richardson RJ
• Description:
  Methylmercuric-chloride (115093) administered as a single intracranial injection in microgram quantities produced a neurological syndrome in rats within 24 hours that resembled the effects produced by repeated subcutaneous injection of 10 milligrams per kilogram over a period of 7-14 days. Neuromuscular function evaluated semiquantitatively by graded performance in simple strength and coordination tests showed severe impairment at 24 hours in intracranially methylmercury-treated animals, with recovery taking place by 72 hours. Body weight decreased and recovered during a similar time course. Incorporation of tritiated leucine into brain protein was increased significantly at 24 hours as measured in vitro in and in vivo. Incorporation returned to control values by 72 hours after the methylmercury injection. Residual brain mercury (7439976) concentrations at 24 hours were about 5-fold lower than those accompanying overt neurological signs in rats produced by subcutaneous administration. Histological examination of brains from intracranially and subcutaneously dosed rats revealed that the lesions produced by the 2 methods were substantially different. Intracranial injection of methylmercury was found to produce an isolated neurotoxic syndrome similar in some respects to the neurotoxicity seen in systemic intoxications but dissimilar histopathologically. [Description provided by NIOSH]
• Subjects:
  Mercury Metals Nervous System Nervous System Diseases Occupational Health Poisoning Radiation Safety Toxicology
• Keywords:
  Brain-disorders Histopathology Mercury-poisoning Metal-poisoning Nervous-system-disorders Neuromuscular-system-disorders NIOSH-Grant NIOSH-Publication Organo-mercury-compounds Radioactive-tracer-analysis Test-methods Time-dose-relationship

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  289-300
• Volume:
  29
• Issue:
  2
• NIOSHTIC Number:
  nn:00036323
• Citation:
  Toxicol Appl Pharmacol 1974 Aug; 29(2):289-300
• Contact Point Address:
  Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
• CAS Registry Number:
  Mercury (CAS RN 7439-97-6) ; Methylmercury chloride (CAS RN 115-09-3)
• Federal Fiscal Year:
  1974
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19810430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4ae37c6e0f14d16dea16d5363ee46a6fa5932f51bf2cef2e45a0325775fc05961ea871acb97da37ea6a99c66f2f1b5f0953676fff822453b2b288fccf5e54a84
• Download URL:
  https://stacks.cdc.gov/view/cdc/183955/cdc_183955_DS1.pdf
• File Type:
  [PDF - 849.33 KB ]