Parathion and diisopropylfluorophosphate (DFP) toxicity in partially hepatectomized rats.

Details

• Personal Author:
  Jacobsen PL ; Spear RC ; Wei E
• Description:
  The toxic effects of parathion and diisopropylfluorophosphate (DFP) are found to increase or remain unchanged in rats after partial removal of the liver, with LD-50 values and blood cholinesterase activities used as indices of toxicity. The results are interpreted as suggesting that the toxicity of parathion is most likely not due to hepatic conversion to paraoxon. [Description provided by NIOSH]
• Subjects:
  Biochemistry Blood Cholinesterase Inhibitors Enzymes Hematologic Tests Insecticides Occupational Health Organophosphates Safety Toxicology
• Keywords:
  Biochemical-reactions Biotransformation Blood-chemistry Cholinesterase-inhibitors Detoxification Enzyme-activity Lethal-dose Liver-functions NIOSH-Grant NIOSH-Publication Organo-phosphorus-compounds Pharmacology

  More +
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  314-317
• Volume:
  26
• Issue:
  2
• NIOSHTIC Number:
  nn:00023539
• Citation:
  Toxicol Appl Pharmacol 1973 Oct; 26(2):314-317
• Contact Point Address:
  None University of California 108 Earl Warren Hall Berkeley, Calif 94720
• CAS Registry Number:
  Diisopropyl fluorophosphate (CAS RN 55-91-4) ; Paraoxon (CAS RN 311-45-5) ; Parathion (CAS RN 56-38-2)
• Federal Fiscal Year:
  1974
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19720201
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19800229
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:65dd730436bc4c6a5854875920930be8aa6059fd7d952afd890653b170b47127e9b02406d9bdaa0f2bb3323d9da580ca3cb3f5fd4bf6beddeb41547f14fc1f1a
• Download URL:
  https://stacks.cdc.gov/view/cdc/183856/cdc_183856_DS1.pdf
• File Type:
  [PDF - 239.35 KB ]