Mechanisms of decaborane toxicity.

Details

• Personal Author:
  Leibman KC ; Naeger LL
• Description:
  In the presence of water, decaborane is rapidly transformed into one or more polar intermediate products that are eventually degraded to boric acid. The intermediate, but not decaborane or boric acid, reduces phosphomolybdic acid and inhibits glutamic-oxaloacetic transaminase. The inhibition of transaminase activity is kinetically irreversible when the ratio of apoenzyme to pyridoxal phosphate is kept constant, but is partially reversed when excess pyridoxal phosphate is added. The inhibitory activity disappears when the intermediate is neutralized with pyridoxal phosphate so that both the phosphomolybdate-reducing capacity of the intermediate and the spectral characteristics of the pyridoxal phosphate are abolished. Prior loading of mice with pyridoxine raises the LD50 of decaborane. It is concluded that toxicity of decaborane attendant upon inhibition of pyridoxal phosphate requiring enzymes is due not to decaborane per se, but to reduction of pyridoxal phosphate by a substance formed nonenzymically from decaborane in the presence of water. [Description provided by NIOSH]
• Subjects:
  Mental Health Nervous System Nervous System Disorders Occupational Health Safety Spectrophotometry
• Keywords:
  Absorption Central-nervous-system-disorders Decarboxylases NIOSH-Grant NIOSH-Publication PM9013643 Psychological-effects Rocket-propellants Thin-layer-chromatography
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  4
• NIOSHTIC Number:
  nn:00017806
• Citation:
  Toxicol Appl Pharmacol 1972 Aug; 22(4):517-527
• Contact Point Address:
  Pharmacology and Therapeutics Univ of Florida Coll of Med Dept of Pharma & Therapeutics Gainesville, Fla 32601
• CAS Registry Number:
  Boric acid (H3BO3) (CAS RN 10043-35-3) ; Decaborane (CAS RN Decaborane (CAS RN 17702-41-9)) ; Pyridoxal 5′-phosphate (CAS RN 54-47-7) ; Pyridoxine (CAS RN 65-23-6)
• Federal Fiscal Year:
  1972
• Performing Organization:
  University of Florida Gainesville, Gainesville, Florida
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19841130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7ea77b076e97519a758c7ef578e44c9043c773ae05aeb8c712214711678fb789c9755053ef5a9aa46b8b888b8eea0595bfd0948ed0d8e6bbdf15c0d4cd1264d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/183799/cdc_183799_DS1.pdf
• File Type:
  [PDF - 759.95 KB ]