Respiratory uptake of ozone in dogs.

Details

• Personal Author:
  Frank R ; Yokoyama E
• Description:
  Measurement of the uptake of ozone by the surgically isolated upper airways in 11 anesthetized, paralyzed, mechanically ventilated dogs. The gas was administered either by nose or mouth, each exposure lasting 20 to 30 minutes. The relative uptake of ozone was found to be inversely related to concentration and flow rate, and was higher nasally than orally. Changes in nasal flow resistance, induced by aerosols of histamine and phenylephrine hydrochloride, had little effect on the process. The removal of ozone from inspired air by the lower airways and parenchyma was measured in five additional dogs that were mechanically ventilated through a tracheal cannula. The concentration ranged from 0.20 parts per million (ppm) to 0.85 ppm; the tidal volume was constant, and the pump frequently was either 20 or 30 cycles per minute. Under these circumstances, the rate of uptake varied between 80 percent and 87 percent. [Description provided by NIOSH]
• Subjects:
  Occupational Health Respiratory System Safety
• Keywords:
  Breathing Gases Inspiration NIOSH-Grant NIOSH-Publication Respiration Respiratory-functions
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  132-138
• Volume:
  25
• Issue:
  2
• NIOSHTIC Number:
  nn:00012203
• Citation:
  Arch Environ Health 1972 Aug; 25(2):132-138
• Contact Point Address:
  Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
• CAS Registry Number:
  (-)-Phenylephrine hydrochloride (CAS RN 61-76-7) ; Histamine (CAS RN 51-45-6) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  1972
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19701001
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19770331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e4c99e59f44fc3756926c34e5094c8de27f75bf4f9b20a517c2c3cacb077a28224b68186b7390be6b0450b5545ef987f1241f4346c080e4fa6e50c5a80d5615a
• Download URL:
  https://stacks.cdc.gov/view/cdc/183783/cdc_183783_DS1.pdf
• File Type:
  [PDF - 3.78 MB ]