Notice to Readers Update: Provisional Public Health Service Recommendations for Chemoprophylaxis After Occupational Exposure to HIV

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Corporate Authors:
  Food and Drug Administration ; Health Resources and Services Administration ; National Institute of Allergy and Infectious Diseases ; National Institute for Occupational Safety and Health ; National Center for Infectious Diseases
• Description:
  Based on information suggesting that zidovudine (30516871) (ZDV) may be useful as postexposure prophylaxis (PEP) to reduce the risk of human immunodeficiency virus (HIV) transmission following occupational exposure to HIV infected blood, previous Public Health Service recommendations on management of occupational exposure to HIV were updated. ZDV PEP has been credited with a 79% decrease in the risk for HIV seroconversion following percutaneous exposure to HIV infected blood in a case/control study among health care workers. In the doses currently recommended, ZDV PEP usually is tolerated well by health care workers with short term toxicity primarily including gastrointestinal symptoms, fatigue, and headache. ZDV use in the second and third trimesters of pregnancy and early infancy has not been associated with serious adverse effects in mothers or infants. The use of ZDV chemoprophylaxis should be recommended for exposed workers after occupational exposure associated with the highest risk for HIV transmission. PEP should be initiated promptly, preferably within 1 to 2 hours of exposure. If the source patient or the patient's HIV status is not known, initiating PEP should be decided on a case by case basis. [Description provided by NIOSH]
• Subjects:
  Acquired Immunodeficiency Syndrome Communicable Diseases Health Personnel HIV Occupational Exposure Occupational Health Preventive Medicine Safety Viral Diseases
• Keywords:
  AIDS-virus Disease-prevention Disease-transmission Health-care-personnel Infectious-diseases Medical-treatment NIOSH-Author Occupational-exposure Occupational-medicine Preventive-medicine Viral-infections

  More +
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  United States
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  6 pdf pages
• Volume:
  45
• Issue:
  22
• NIOSHTIC Number:
  nn:00234986
• Citation:
  MMWR 1996 Jun; 45(22):468-472
• CAS Registry Number:
  Azidothymidine (CAS RN 30516-87-1)
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:2ccabd81812ef1b9b4f36865780d1793ae97bb0d0b2ba8f0feb4c0b44dca38fc5597ec62501bb79b8a4f920f5a92581e1078cc497e36750e8f33c1425b4389a9
• Download URL:
  https://stacks.cdc.gov/view/cdc/183212/cdc_183212_DS1.pdf
• File Type:
  [PDF - 106.82 KB ]