Is it really doses and responses instead of dose response?

Details

• Personal Author:
  Biagini, Raymond E. ; MacKenzie, Barbara A. ; Sammons DL ; Smith JP ; Snawder JE ; Striley CAF
• Description:
  A major limitation in biological monitoring for human exposures to xenobiotics and the evaluation of their effects from these exposures is that the body burdens are looked upon as multiple independent variables. In fact, the multivariate effects of exposures to numerous xenobiotics and their effects on multiple systems are a truer picture of the outcome of occupational or environmental exposures. The pre-existing view of exposure-effect relationships is brought about by practical limitations of the experimental method, where measurements of body burdens and effects of even a few xenobiotics by classical methods is resource taxing. Furthermore, conclusions regarding exposure-effect relationships when a limited number of body-burdens and effects are investigated are wrought with numerous potential errors which may be propagated during risk analyses. In the present work, we describe and review a technology that overcomes some of these limitations by multiplexing (measuring numerous analytes simultaneously), using fluorescence microsphere covalent immunoassays (FMCIA). Examples of the utility of this method for multiplexed measurements of biomarkers of exposure and effect (as many as 25 analytes simultaneously) from exposure to pesticides, multivalent vaccinations, and anthrax are presented and reviewed.
• Subjects:
  Accidents, Occupational Coal Coal Mining Fuel Oils Mining Occupational Health Preceptorship Safety
• Keywords:
  Biomarkers Dose-response Environmental-exposure Exposure-assessment Occupational-exposure Occupational-hazards Risk-analysis Workplace-studies
• Publisher:
  NIOSH/CDC
• Document Type:
  Text
• Genre:
  Abstract ; Conference/Symposia Proceedings
• Place as Subject:
  New Mexico ; Ohio ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10
• NIOSHTIC Number:
  nn:20027213
• Citation:
  Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003. Atlanta, GA: Centers for Disease Control, 2003 Mar; :10
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74ffc84018c5339858575387ebe9bf0898559f1f04831e1ea187709326d92d35a0ab3c2dbed0d7844a256bd8caacfbbfc3a860fca6f41ffe21be014cac5f58a4
• Download URL:
  https://stacks.cdc.gov/view/cdc/181301/cdc_181301_DS1.pdf
• File Type:
  [PDF - 386.47 KB ]