Laboratory evaluation and field testing of a collection method for 1-bromopropane in exhaled breath.

Details

• Personal Author:
  Grote, Ardith A. ; Hanley, Kevin W. ; Sanderson, Wayne T.
• Description:
  1-Bromopropane (1-BP) has been marketed as an alternative for ozone-depleting solvents and is in adhesives, cleaning solvents, and aerosol products. Toxicity of 1-BP is poorly understood, but it may be a neurologic, reproductive, and hematologic toxin. Sparse exposure information has prompted NIOSH to conduct a multi-industry study using air, exhaled breath, and urinary metabolite measurements. Exhaled breath analysis can be a powerful, non-invasive tool which is affected by inhalation and dermal exposures. Breath sampling methods must be accurate, sensitive, and unaffected by water vapor to measure trace levels consistently without contamination or deterioration. This study evaluated a practical breath collection method for 1-BP analysis conducted at an off-site laboratory with proper quality control.
• Subjects:
  Accidents, Occupational Genetics Occupational Health Safety
• Keywords:
  Adhesives Aerosol-particles Aerosols Analytical-chemistry Analytical-methods Biomarkers Chromatographic-analysis Cleaning-compounds Hematopoietic-system Neurotoxic-effects Reproductive-system-disorders Sampling-methods

  More +
• Publisher:
  NIOSH/CDC
• Document Type:
  Text
• Genre:
  Abstract
• Place as Subject:
  Iowa ; New Mexico ; Ohio ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9
• NIOSHTIC Number:
  nn:20027212
• Citation:
  Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003. Atlanta, GA: Centers for Disease Control, 2003 Mar; :9
• CAS Registry Number:
  1-Bromopropane (CAS RN 106-94-5)
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  False
• Source Full Name:
  Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08de1ae1bfb3fa2f8f69f76aeb7bffce5db587f582bcbc710c78ba112b65172718de5af047f8b4b5ed6d67cf73387c1963312d9fc086b18f9a4c4f88f71c52f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/181300/cdc_181300_DS1.pdf
• File Type:
  [PDF - 417.53 KB ]