Immuno-based Personal Exposure Monitors.

Details

• Personal Author:
  Drinkwine A ; Emon J ; Lopez-Avila V ; Spurlin S
• Description:
  An attempt was made to develop personal exposure monitors (PEMs) that use either a polyclonal or a monoclonal antibody immobilized onto a silica support for the collection and detection of a specific target analyte or compound class. A system was being developed which would result in a compact, diffusion based personal exposure monitor for specific target analysis. Semipermeable membrane tubes with a high surface to volume ratio were used to overcome the interface problem of the aqueous based antibody system. For pentachlorophenol (87865) (PCP), an immunobased collection and analysis system using a monoclonal antibody was investigated. Monitoring limits were constrained by the detection capability of the antibody based system. The limit of detection for the PEM device should be from 1 to 5 nanograms of PCP. This would convert to a minimum exposure time of around 20 minutes for the analyte to reach a detectable quantity within the PEM device based on a vapor concentration of 5 parts per billion (ppb). Early results indicated that it will be possible to apply antibodies to direct air monitoring systems through the use of microdialysis tubing as a semipermeable barrier which allows vapor diffusion without significant moisture loss.
• Subjects:
  Accidents, Occupational Cardiovascular Diseases Cardiovascular System Endocrine System Endocrine System Diseases Energy Metabolism Hematologic Diseases Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety

  More +
• Keywords:
  Air-monitoring Air-quality-monitoring Chlorinated-phenols Environmental-contamination Monitoring-systems Occupational-exposure Work-environment
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  449-459
• NIOSHTIC Number:
  nn:00210431
• Citation:
  NIOSH 1991 Feb:449-459
• CAS Registry Number:
  Pentachlorophenol (CAS RN 87-86-5)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Source Full Name:
  Field Screening Methods for Hazardous Wastes and Toxic Chemicals. Second International Symposium, February 12-14, 1991. Sponsored by U.S. EPA; U.S. DOE; U.S. Army Toxic and Hazardous Materials Agency; U.S. Army Chemical Research Development and Engineering Center; U.S.A.F.; Florida State Univ.; National Environmental Technology Applications Corp.; and NIOSH
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c2c8876a870dad98c7a4a32e758a5fde774d5b582ae4bb959783e40127317d1c7cbb900fa7c954fe31e8e2be50b64ffbc42d9f050862d49572e57088dbb66e4d
• Download URL:
  https://stacks.cdc.gov/view/cdc/180798/cdc_180798_DS1.pdf
• File Type:
  [PDF - 494.01 KB ]