Prophylactic chelation therapy: a review of the literature.

Details

• Personal Author:
  Bridbord K
• Description:
  This report presented a review of the literature concerning the usefulness of prophylactic chelation therapy as a means of controlling occupational lead (7439921) intoxication. Reports concerning both the routine use of chelation therapy to avoid high blood lead concentrations and the use of chelation therapy to lower already elevated blood lead levels were reviewed. Studies included the use of calcium-disodium-ethylenediamine-tetraacetic-acetate (EDTA) and penicillamine therapies. The general consensus of opinion among those treating this occurrence in the field was that chelation or similarly acting agents have a definite place in the treatment regimen. The prophylactic use of these agents, however, has been viewed as being somewhat harmful to the health of the individual being so treated in that it can cause kidney damage, symptomatic lead poisoning, increased absorption of lead from the gastrointestinal tract, and disruption in the metabolism of trace metals other than lead. The author concludes that no support can be given to the routine prophylactic use of chelating agents to avoid high lead levels in exposed workers.
• Subjects:
  Accidents, Occupational Neoplasms Occupational Health Respiratory Tract Diseases Safety Vehicle Emissions
• Keywords:
  Blood-analysis Chelates Chelating-agents Heavy-metal-poisoning Lead-compounds Lead-poisoning Medical-treatment NIOSH-Author Preventive-medicine
• Document Type:
  Text
• Genre:
  Other
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-25
• NIOSHTIC Number:
  nn:00208296
• Citation:
  NIOSH 1976 Mar; :1-25
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, Rockville, Maryland, 25 pages, 26 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74783e7e6108067e129f911feccdf495caf9882e7986b90624ca53760980134bbd239d7757951375491957858a12e190aa8d02eba8075745d6fa06001f94c078
• Download URL:
  https://stacks.cdc.gov/view/cdc/180764/cdc_180764_DS1.pdf
• File Type:
  [PDF - 697.49 KB ]