Aluminum inhalation reduces silicosis in a sheep model.

Details

• Personal Author:
  Begin R ; Cantin A ; Dubois F ; Dufresne A ; Masse S ; Perrault G ; Sebastien P
• Description:
  The efficacy of soluble aluminum-lactate (18917914) aerosol inhalation to alter the biological activity and disease process associated with silica (7631869) exposure was evaluated in the sheep tracheal lobe model. A flock of 40 sheep was divided into four groups of ten sheep. The first group was exposed to phosphate buffered saline (PBS) infusion in the tracheal lobe followed by monthly inhalation of PBS. The second group was exposed to PBS followed by monthly inhalation of aluminum-lactate. The third group was exposed to Minusil-5 followed by monthly inhalation of PBS. The fourth group was exposed to Minusil-5 followed by monthly inhalation of aluminum-lactate. Bronchoalveolar lavage was performed prior to exposures and at monthly intervals thereafter. Animals were sacrificed for histopathological examination at month 6. All silica exposed sheep demonstrated an increase in cellularity. Aluminum- lactate inhalation at monthly intervals significantly suppressed the alveolitis of silicosis, reduced the intensity and profusion of the disease process, and accelerated the clearance of quartz particles from the lung tissue. The authors conclude that soluble aluminum- lactate aerosol inhalation reduces silicosis in the sheep model without alteration of normal biological processes in the bronchoalveolar milieu or production of significant pathological lung damage.
• Subjects:
  Accidents, Occupational Blood Blood-Borne Pathogens Communicable Diseases Hazardous Substances Hazardous Waste Health Personnel Hematologic Diseases HIV Laboratories Occupational Health Safety

  More +
• Keywords:
  Aluminum Compounds Animal Studies Biological Effects Lung Disease Medical Treatment Occupational Diseases Occupational Exposure Occupational Health Silica Dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  895-896
• NIOSHTIC Number:
  nn:00199463
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Pt II):895-896
• CAS Registry Number:
  Tris[2-(hydroxy-κO)propanoato-κO]aluminum (CAS RN 18917-91-4) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:290e5b6592a34f5c1a383d18840fc88e65d33e19082c44b753f53cee33ac6397826cddf436257cdaddf89da5655cac0345c605670455daaef0e171dfec5fb004
• Download URL:
  https://stacks.cdc.gov/view/cdc/180723/cdc_180723_DS1.pdf
• File Type:
  [PDF - 103.57 KB ]