Influence of chemical/thermal pretreatment on the cytotoxicity of coalmine dusts.

Details

• Personal Author:
  Beck EG ; Tilkes F
• Description:
  An attempt was made to try to characterize the cytotoxicity of high rank and low rank mine dusts from the Saar and Ruhr coal fields more accurately via their dose dependence and the effect of chemical and thermal pretreatment. Two groups of dusts were selected for the chemical and thermal treatment. Group-A dusts caused higher reactions for one parameter in the animal experiments than for two parameters in the in-vitro test. Group-B dusts caused a lesser reaction for the one parameter in the animal experiment than in the corresponding two parameters of the in-vitro test. The chemical and thermal treatments resulted in a change in the toxicity of a number of the mine dusts, and generally towards an increase in toxicity. In view of the altered dust surfaces, these changes did not permit a direct assessment of the membrane toxicity. The treatment resulted in the removal of impurities from the dust surface. With quartz (14808607) the treatment also resulted in a change in the basic crystal structure and therefore in the electron structure. The mine dusts from Group-A differed more widely than those of Group-B with regard to their quartz typical deposition areas in the lymph node test than the quartz contents of the dusts.
• Subjects:
  Accidents, Occupational Coal Coal Mining Fuel Oils Mining Occupational Health Safety
• Keywords:
  Airborne Dusts Coal Dust Cytotoxic Effects Dust Exposure Dust Inhalation Mining Industry Silica Dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1538-1541
• NIOSHTIC Number:
  nn:00198723
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1538-1541
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:72f61be0ea4a58b93dc9703f243057e07d63417227342cc12751d194c62bed7ca9901cc639438bef0320aeb505d395293f43a326b086c0514073538834fc4f1a
• Download URL:
  https://stacks.cdc.gov/view/cdc/180636/cdc_180636_DS1.pdf
• File Type:
  [PDF - 141.93 KB ]