Alveolitis in occupational lung disease (OLD).

Details

• Personal Author:
  Costa MF ; Mendes AC ; Monteiro JT ; Teles de Araujo A
• Description:
  An investigation was conducted to evaluate the existence and type of alveolitis among a group of 48 patients with occupational lung disease confirmed by the usual criteria. A comparison was also made of the patients with occupational history of exposure to organic dust (Group-I) with patients exposed in work environment to mineral dust (Group-II). The cellular analysis of bronchoalveolar lavage (BAL) fluid noted an increased number of cells, with a significant difference in Group-I as compared to referents. The alveolitis in both groups was mainly due to a significant increase in lymphocytes. A slight but not significant increase in the polymorphonuclear cells was also noted. Among the 14 patients in which lung biopsy was performed, alveolitis was noted in the BAL of nine. From these nine, eight demonstrated granulomas or lymphoplasmocytary infiltration of the alveolar septa. From the five patients without alveolitis in BAL only one presented granulomas in the lung biopsy. A marked increase was noted in the T-suppressor cells. The authors conclude that BAL is a good method to investigate occupational lung diseases as it contributes to the staging and understanding of the pathogenic mechanisms.
• Subjects:
  Accidents, Occupational Communicable Diseases Health Personnel Laboratories Occupational Health Safety
• Keywords:
  Diagnostic Techniques Dust Exposure Dust Inhalation Lung Disease Mineral Dusts Occupational Diseases Respiratory System Disorders Silica Dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1514-1518
• NIOSHTIC Number:
  nn:00198719
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1514-1518
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f27fedfd2c1c91dd301a63a863d9086ec22a89dce925c7cf455a012daada43ada015e6f49a50442abd5ba0fc6a7881242102551d73d780802f00f3bb90f72a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/180632/cdc_180632_DS1.pdf
• File Type:
  [PDF - 161.46 KB ]