Asbestos related diffuse pleural fibrosis.

Details

• Personal Author:
  Gibbs AR ; Griffiths DM ; Pooley FD ; Stephens M
• Description:
  Mineral fiber concentrations in lung tissue from persons with diffuse pleural fibrosis (DPF) attributed to asbestos (1332214) exposure were determined. Tissue specimens from the pleural, subpleural, and central areas of lungs were obtained at autopsy from 13 males who had bilateral DPF. The degree of parenchymal fibrosis was determined using a 4 point scale. The clinical and occupational histories of the subjects were reviewed. The samples were analyzed for chrysotile (12001295), crocidolite (12001284), and amosite (12172735) by scanning and transmission electron microscopy. The ages at death of the subjects ranged from 47 to 80 years. The years of potential exposure to asbestos ranged from 1 to 35 years. The degree of parenchymal fibrosis in 12 subjects ranged from 0/1 to 2/3. Parietal pleural plaques were seen in some subjects. One subject had severe diffuse pericardial fibrosis. Total asbestos fiber counts were significantly elevated in tissue samples from 11 subjects. Total asbestos fiber counts were significantly higher in the central and subpleural regions than in the pleural regions. Chrysotile fibers were generally equally distributed throughout all lung regions. Amosite and crocidolite concentrations in the pleural region were significantly lower than in the central or subpleural region. The authors conclude that the DPF in 11 subjects was probably caused by occupational exposure to asbestos. In DPF cases chrysotile is the predominant fiber found in the pleura, but small amounts of amphibole fibers are also present.
• Subjects:
  Accidents, Occupational Environmental Monitoring Lead Lead Poisoning Metals Metal Workers Occupational Health Safety
• Keywords:
  Asbestos Fibers Asbestos Workers Lung Fibrosis Lung Tissue Mineral Dusts Occupational Exposure Postmortem Examination
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  915-918
• NIOSHTIC Number:
  nn:00198679
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):915-918
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Amosite asbestos (CAS RN 12172-73-5)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b6e9c8d1490cd1345fffb4bb0a206d870214b9c0ac3a4ae10ef9f3943eb517648766cd93673bdef103384a01c1346877f30ff78aaee4c5e694a33ed89b9490dd
• Download URL:
  https://stacks.cdc.gov/view/cdc/180594/cdc_180594_DS1.pdf
• File Type:
  [PDF - 128.34 KB ]