Biological effects of short fibers.

Details

• Personal Author:
  Wagner JC
• Description:
  The fibrogenicity of short crocidolite (12001284) and erionite (12510428) fibers was studied in rats. Fisher-344-rats were exposed to crocidolite or erionite preparations containing fibers longer than 6 microns or shorter than 5 microns by inhalation or intrapleural injection. Selected rats were killed after 3, 6, 12, or 24 months and the lungs were removed and examined for histopathological evidence of fibrosis, pleural mesothelioma, and bronchiolar alveolar hyperplasia (BAH). Lung tissue samples from animals killed at 24 months were analyzed for their fiber content. After intrapleural injection at least 90% of the rats exposed to long fibers of either crocidolite or erionite developed mesothelioma. When the short fiber preparation was used crocidolite induced mesothelioma in only one rat. Short erionite fibers did not cause any mesotheliomas. After inhalation exposure more than 90% of the rats exposed to the long fiber preparation of erionite developed mesotheliomas. The long fiber preparation of crocidolite caused only a single mesothelioma. The short fiber preparations of erionite or crocidolite did not induce mesotheliomas. The long fiber preparations of erionite and crocidolite induced two cases of BAH. Inhalation exposure of either long erionite or crocidolite fibers caused minimal fibrosis. The short fiber preparations produced only a tissue reaction. Lung tissue sections contained significant numbers of long erionite or crocidolite fibers, but almost no short fibers. The author concludes that animals treated with dusts containing short and long fibers tend to selectively retain the longer fibers.
• Subjects:
  Accidents, Occupational Occupational Health Oil And Gas Industry Safety
• Keywords:
  Asbestos Fibers Fibrous Dusts Inhalation Studies In Vivo Studies Laboratory Animals Lung Burden Lung Tissue Malignant Neoplasms
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  835-839
• NIOSHTIC Number:
  nn:00198666
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):835-839
• CAS Registry Number:
  Crocidolite asbestos (CAS RN 12001-28-4) ; Erionite ((K0-1Na0-1Ca0-0.5)10(Al10Si26O72).30H2O) (CAS RN 12510-42-8)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7066716e7181f27e24e3c9d7673b504ac416e9b672aee98e38647e71f6c2cac4afa41837e914fc5c8ee1c1a5ab8eae04dcf2050aeea6925800345583ba47b7b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/180581/cdc_180581_DS1.pdf
• File Type:
  [PDF - 141.69 KB ]