The correlation between silicosis and lung cancer - pathological evidences from 5 autopsied cases.

Details

• Personal Author:
  Yu T
• Description:
  This paper reports certain pathological correlations between silicosis and lung cancer based on pathological materials fRom, William N.orker with silicosis caused by railway tunnel building in China. Five cases were reviewed. The first involved a 53 year old man who was a tunnel builder for 9 years. He had massive silicotic fibrotic lesions in both upper lobes of the lungs. The second case, a 58 year old man who had been building tunnels for 34 years, with a history of smoking, had a massive silicotic fibrotic lesion associated with tuberculosis in the right upper lobe. The third case involved a 58 year old man who had been a tunnel builder for 8 years with a history of smoking who demonstrated generally distributed silicotic nodules throughout the whole lungs, and whose nodules in the left upper lobe showed a tendency to coalesce. The fourth case was a 60 year old male who was a railway builder for 38 years and smoked. Silicotic nodules were present in both upper, middle and lower lobes and there was a massive silicotic fibrotic lesion in the middle lobe of the right lung. The fifth case was a 58 year old man, a tunnel builder for 6 years, who smoked. There was a black and white interlacing region in the upper lobe of the left lung and all lobes of both lungs had scattered silicotic nodules. In these cases the development of cancer had some correlation with preexisting silicosis. The cancer in two cases developed on the same lobe as the massive silicotic lesion had existed. In one case the cancer developed from multiple deformed bronchioles which remained in the subpleural silicotic collagenous region.
• Subjects:
  Accidents, Occupational Chemistry Explosions Fires Fuel Oils Geology Hazardous Substances Heat Stress Disorders Hot Temperature Manufacturing And Industrial Facilities Noise Occupational Exposure Occupational Health Safety Solvents Surveys And Questionnaires Temperature Vibration

  More +
• Keywords:
  Cancer Rates Carcinogenesis Lung Cancer Lung Disease Railroad Industry Respiratory System Disorders Tunneling Tunnel Workers
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Maine ; OSHA Region 1 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1563-1572
• NIOSHTIC Number:
  nn:00198618
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1563-1572
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:59bd939d96fcac176157b0637fcb4b5e7c9d91ac3b2926ef9dab3bc04882a85144b84749e82f4bf876356e619c371473e51ee96ec81bf496391027043dbad0a1
• Download URL:
  https://stacks.cdc.gov/view/cdc/180561/cdc_180561_DS1.pdf
• File Type:
  [PDF - 189.96 KB ]