A rationale for assessing exposure-dose-response relationships for occupational dust-related lung disease.

Details

• Personal Author:
  Donaldson K ; Jones AD ; Mark D ; Vincent JH
• Description:
  A dosimetric approach for assessing dose response relationships for dust related occupational lung diseases was described. A quantitative dosimetric model was derived based on considerations of exposure intensity, rate of deposition in the lungs, time dependent history of exposure, chemical composition of the agent, and indices of the biological response. The model consisted of an equation that expressed cumulative dose as the sum of the mass of material deposited in the lung for a specified time after exposure times the product of a retention function and damage function summed over the elapsed time since the agent was deposited in the lung. The model was illustrated by applying it to a cell lavage study of rats that had been exposed by inhalation to 50mg/m3 quartz (14808607) and titanium-dioxide (13463677). Influx of neutrophils into the lavage fluid represented the damage function. Inhalation of titanium- dioxide provoked an increased neutrophil influx that decreased sharply after exposure stopped. This suggested that the intrinsic harmfulness of titanium-dioxide was not persistent but that the damage function decayed with time. The neutrophil influx induced by quartz was much larger and persisted after exposure ended. This indicated that the damage function for quartz was much larger than that of titanium-dioxide and did not decline after exposure ended. The authors conclude that the dosimetric approach should be useful for assessing risks associated with inhaling airborne particles. If it can be validated it should be useful in epidemiological studies.
• Subjects:
  Accidents, Occupational Education Occupational Health Safety Safety Management Staff Development
• Keywords:
  Dose Response In Vivo Studies Laboratory Animals Lung Cells Mathematical Models Mineral Dusts Occupational Diseases Respiratory System Disorders Simulation Methods
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  151-157
• NIOSHTIC Number:
  nn:00198422
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):151-157
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Part Number:
  I
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b8443ca842047675a7de5433385c1533acb46e23706f6c81371c05a1531f18a283a7cd1253286e83d40e0788fbc6b56a4b64f9b4de8fbdbb24fd0bbc83fe3e52
• Download URL:
  https://stacks.cdc.gov/view/cdc/180485/cdc_180485_DS1.pdf
• File Type:
  [PDF - 200.01 KB ]