In-depth survey report: control technology assessment of enzyme fermentation processes at Novo Biochemical Industries, Inc., Franklinton, North Carolina.

Details

• Personal Author:
  Martinez, Kenneth F.
• Description:
  An in depth survey was made of the Novo Biochemical Industries, Inc. (SIC-2869) (NBI) facility located in Franklinton, North Carolina to evaluate the controls and containment capabilities employed in their alpha-amylase enzyme manufacturing process. The process at the facility used a strain of Bacillus-licheniformis to produce alpha- amylase. Possible hazardous exposures at the facility included hazardous microorganisms, toxic processing chemicals, and biologically active products or intermediates. Viable air samples collected from background locations contained concentrations ranging from 120.8 colony forming units/cubic meter (CFU/m3) for the outside samples to 271.2CFU/m3 around the aging tanks. Viable samples collected around selected unit processes ranged from 3.2CFU/m3 in the clean rooms to 705.7CFU/m3 at the sample port. Total dust levels ranged from 0.07mg/m3 at the fermentor tank agitator shaft to computer controlled and monitored process technology which limits direct employee involvement and potential hazard exposure. Potential exposures in the laboratory process, fermentation process, and recovery process steps are considered and NBI's work practices, environmental health monitoring program, and personal protection requirements are discussed. The author concludes that the results of the viable air sample analysis indicate an effective system of control measures.
• Subjects:
  Accidents, Occupational Carcinogens Environmental Monitoring Epidemiology Liver Mortality Neoplasms Occupational Health Polychlorinated Biphenyls Safety Surveys And Questionnaires

  More +
• Keywords:
  Bacteria Biological-material Enzyme-activity Field-Study Microorganisms NIOSH-Author NIOSH-Survey Region-4
• DOI:
  https://doi.org/10.26616/NIOSHECTB11615b
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Field Studies ; Control Technology
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DPSE - Division of Physical Sciences and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-37
• NIOSHTIC Number:
  nn:00166586
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, ECTB 116-15b, 1986 Dec; :1-37
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  2869 - Industrial organic chemicals, not elsewhere classified - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:993fdd92921dc542488159401dbc71c59c20b787d93315ac6697f3fc66d5b84ec98c964860ffe73703160aa6836dc9f8e26aec95d1adfa282192c0e090b75cf2
• Download URL:
  https://stacks.cdc.gov/view/cdc/179835/cdc_179835_DS1.pdf
• File Type:
  [PDF - 1.57 MB ]