Teratologic assessment of ethylbenzene and 2-ethoxyethanol.

Details

• Personal Author:
  Andrew FD ; Buschbom RL ; Cannon WC ; Miller RA ; Montgomery LF ; Phelps DW ; Sikov MR
• Description:
  The teratogenic potential of ethylbenzene (100414) or 2- ethoxyethanol (110805) was studied in rats and rabbits. Female Wistar-rats and New-Zealand-white-rabbits were exposed to 100 or 1,000 parts per million (ppm) ethylbenzene vapor or 160, 202, 617, or 767ppm 2-ethoxyethanol vapor 7 hours daily 5 days per week for 3 weeks. The rats were mated and exposed daily through day 19 of gestation. The rabbits were artificially inseminated and exposed through day 18 or 24 of gestation for 2-ethoxyethanol or ethylbenzene, respectively. The dams were observed for signs of toxicity such as altered food consumption, body weight gain changes, and weight and histopathologic changes in selected tissues. At delivery, litters were examined for the presence of external, visceral, and skeletal malformations, and crown/rump lengths were measured. The numbers of living and dead fetuses, and resorptions were recorded. Ethylbenzene did not cause maternal toxicity or embryotoxicity in rabbits. The 1,000ppm dose caused increased weights of maternal livers, kidneys, and spleens, and increased body weight gain in rats. An increase in supernumerary ribs occurred in rat fetuses; however, this was not considered to be a teratogenic effect. 2-Ethoxyethanol at 617ppm in rabbits and 767ppm in rats caused decreased maternal food consumption, body weight loss, and mortality. Liver and kidney weights were elevated. Significant increases in embryo mortality occurred. The 160 or 202ppm doses caused fetal growth retardation, increased embryo mortality, and an increase in minor malformations. The authors conclude that ethylbenzene at 1,000ppm is toxic to pregnant rats, but probably not for pregnant rabbits. Higher doses might be teratogenic in rats. 2- Ethoxyethanol is a teratogen in both rabbits and rats. It should probably be regarded as presenting similar risks to humans.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Dust Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Contract-210-79-0037 Exposure-limits NIOSH-Contract Pulmonary-system Quantitative-analysis Respiration Toxic-effects Toxic-materials Ventilation
• Document Type:
  Text
• Funding:
  Contract
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-107
• NIOSHTIC Number:
  nn:00155280
• Citation:
  NIOSH 1981 Jan; :1-107
• CAS Registry Number:
  Ethylbenzene (CAS RN 100-41-4) ; Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1981
• NORA Priority Area:
  Asthma and Chronic Obstructive Pulmonary Disease ; Disease and Injury ; Pulmonary System Disorder
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ce06971be4def0e885f609031dbc54dbca34933018cff75cb00dfc28a57bb532efff1192216824e7fa1e66c43dc024697a4451f381c866e868085293347c0aed
• Download URL:
  https://stacks.cdc.gov/view/cdc/179774/cdc_179774_DS1.pdf
• File Type:
  [PDF - 3.67 MB ]