Reproductive outcomes in wives of lead exposed workers.

Details

• Personal Author:
  Cottrill, Charlotte A. ; Hornung R ; Kissling GE ; Leffingwell SG ; Selevan SG
• Description:
  A survey of reproductive outcomes in wives of workers exposed to lead (7439921) was conducted. The cohort consisted of the current wives of 376 married male employees of a lead battery (SIC-3691) manufacturer. Pregnancy data was obtained through interviews. Work histories and blood lead concentrations were obtained from company records. Lead exposures were classified as low (25 to 40 micrograms lead per deciliter (microg/dl) of blood), medium (41 to 60microg/dl), high (60microg/dl) or unexposed (less than 25microg/dl). Odds ratios (OR) of fetal loss risk were calculated from the pattern of fetal loss. OR values (adjusted only for maternal age and prior fetal loss) were: 1.5 for the low exposure group, 1.1 for medium exposure, and 0.9 for high exposure. When separated into females who smoked or did not smoke during pregnancy, the OR values were: low exposure nonsmokers, 0.64 and smokers, 6.82; medium exposure nonsmokers, 0.75 and smokers, 1.92; and high exposure nonsmokers, 0.46 and smokers, 2.29. The authors conclude that elevated OR values for fetal loss with paternal lead exposure are observed in females who smoke during pregnancy. The observed inverse dose response pattern could reflect a shift in outcome with increasing lead exposure.
• Subjects:
  Accidents, Occupational Hazardous Substances Health Care Facilities Workforce And Services Manufacturing And Industrial Facilities Occupational Health Personal Protective Equipment Preceptorship Safety Ventilation
• Keywords:
  Blood-plasma Blood-samples Fertility Fertilizer-industry NIOSH-Author Reproduction Reproductive-effects Reproductive-system Toxicology Toxicopathology
• Document Type:
  Text
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-44
• NIOSHTIC Number:
  nn:00145205
• Citation:
  NIOSH 1984 Dec; :1-44
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  3691 - Storage batteries - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d06062415c7c0f5640b093938b0c3a116aced24b67046fc1d7d07032af781ffefc9e3c79cbc05700abe4ca270d908e845530d2ebfcb5259c2ded2be0ec93b246
• Download URL:
  https://stacks.cdc.gov/view/cdc/179720/cdc_179720_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]