Screening of priority chemicals for reproductive hazards.

Details

• Personal Author:
  Lunchick C ; McCall DL ; Piccirillo VJ ; Plankenhorn LJ ; Sexsmith C
• Description:
  The reproductive toxicity of nine chemicals was evaluated. Pregnant CD-1-mice were treated daily by gavage on days 7 to 14 of gestation with one of the following chemicals: 3.5 milligrams per kilogram (mg/kg) of sodium-selenite (10102188), 100mg/kg of ethylene-thiourea (96457), 500mg/kg of 2-(2-butoxyethoxy)ethanol (112345) (2-BEE), 2955mg/kg of ethylene-glycol-diethyl-ether (629141) (EGDE), 5500mg/kg of diethylene-glycol-monoethyl-ether (111900) (DGME), 11270mg/kg of triethylene-glycol (112276) (TEG), 560mg/kg of aniline (62533), 1200mg/kg of p-nitroaniline (100016), or 365mg/kg of N,N- dimethyl-aniline (121697) (DMA). Maternal body weights, mortality and toxic symptoms were recorded. Litter size, litter weight, pup weight, and offspring viability were determined. Dams and pups were killed on day 4 postpartum for autopsy. No adverse effects were found for sodium-selenite, ethylene-thiourea, 2-BEE, TGE, or DMA. EGDE caused increased numbers of dead and resorbed litters, reduced pup weight, and reduced offspring viability. DGME was slightly toxic, but did not adversely affect reproductive outcome. Aniline significantly reduced offspring viability. With p-nitroaniline, maternal survival was reduced, maternal weight gain was decreased, the number of dead and resorbed litters was increased, and offspring viability was reduced.
• Subjects:
  Accidents, Occupational Hydrocarbons Occupational Exposure Occupational Health Safety Solvents
• Keywords:
  Animal-studies Comparative-toxicology Contract-210-81-6010 Hazardous-materials Mortality-data NIOSH-Contract Pathomorphology Reproductive-effects Toxicology Toxicopathology
• Document Type:
  Text
• Funding:
  Contract
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-108
• NIOSHTIC Number:
  nn:00133673
• Citation:
  NIOSH 1983 Jan; :1-108
• CAS Registry Number:
  Sodium selenite (CAS RN 10102-18-8) ; Ethylenethiourea (CAS RN 96-45-7) ; Diethylene glycol monobutyl ether (CAS RN 112-34-5) ; Ethylene glycol diethyl ether (CAS RN 629-14-1) ; Diethylene glycol monoethyl ether (CAS RN 111-90-0) ; Triethylene glycol (CAS RN 112-27-6) ; Aniline (CAS RN 62-53-3) ; 4-Nitroaniline (CAS RN 100-01-6) ; N,N-Dimethylaniline (CAS RN 121-69-7)
• Federal Fiscal Year:
  1983
• Peer Reviewed:
  False
• Source Full Name:
  Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, PB83-257-600
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5ed079551209e957ea532ed2d59c3cb7e83e76fd79fcaf3b78a72e8fd013d9c2ff6434940f04cdbab343f7b2c801142ab6f3546a7298ee612b53fa4894bf8ae9
• Download URL:
  https://stacks.cdc.gov/view/cdc/179593/cdc_179593_DS1.pdf
• File Type:
  [PDF - 3.66 MB ]