Report on women pharmaceutical workers and adverse reproductive outcomes.

Details

• Personal Author:
  Cottrill, Charlotte A. ; Ditzel C ; Halperin, William E. ; Hornung R ; Lee, Shio T. ; Leffingwell SS ; Robinson C ; Stepehnson F
• Description:
  A reproductive history survey of past and current female employees of pharmaceutical laboratories (SIC-2834) was conducted using a retrospective cohort study design. A total of 191 laboratory workers and 318 comparisons participated in telephone interviews. A panel of physicians classified responses into categories of congenital malformation, perinatal illness, normal physiologic variant, and normal. Age and parity groups were used as strata when making comparisons on reproductive outcome between laboratory and administrative workers. Women who had previously worked in the laboratory reported significantly greater proportions of malformations during the early 1970s than did comparisons. Specifically, the proportion of infants born with malformations to mothers who worked in the laboratory at the estimated date of conception was significantly different from the proportion of comparisons. The proportion of miscarriages, and differences in birth weight were not significantly different. The authors conclude that there was a significantly higher proportion of congenital malformations among children born to women employed in the laboratory area of a pharmaceutical research facility. The cluster was limited in time and results may have been biased by social and economic traits. In addition, the study was not a randomly selected population, but rather a self reported cluster of miscarriages and stillbirths.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Air Pollution, Indoor Aluminum Compounds Metal Workers Noise, Occupational Occupational Health Preceptorship Safety Staff Development Workplace

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• Keywords:
  Birth Epidemiology Laboratory-workers NIOSH-Author Occupational-exposure Risk-analysis Risk-factors Teratogenesis
• Document Type:
  Text
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-28
• NIOSHTIC Number:
  nn:00130220
• Citation:
  NIOSH 1983 Jun; :1-28
• Federal Fiscal Year:
  1983
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  2834 - Pharmaceutical preparations - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0d60f647fc50240441049e3b5b93a36633aff0a8fb046451589523072810ce4b041a4c8df2fdd6f2c7a2badc0956f175a01a247972f1e794c55901be73806603
• Download URL:
  https://stacks.cdc.gov/view/cdc/179527/cdc_179527_DS1.pdf
• File Type:
  [PDF - 853.26 KB ]