Development of a quantitative, sampling and analytical method for acetone cyanohydrin in air.

Details

• Personal Author:
  Fey PM ; Glaser RA
• Description:
  An air sampling method for acetone-cyanohydrin (75865) was developed. Air samples were collected on sorbent tubes containing analyte porapak QS, desorbed with ethyl-acetate (1.0, 10.0, and 50 micrograms in 5, 10, or 25 microliters of solvent), and analyzed by gas chromatography using a nitrogen phosphorous detector and teflon column packed with 5 percent OV-17 on chromosorb T. The method was evaluated by collecting 1 to 50 micrograms acetone cyanohydrin at which sample tubes were exposed to humid air (80 percent humidity). In the range 0.33 to 16.7 milligrams per cubic meter the pooled relative standard deviation for the total sampling was 9.3 percent. At least 12 liters of humid air was sampled without acetone cyanohydrin breakthrough. There was no statistical difference at the 95 percent confidence level between the averages for the two groups of storage samples (1 day samples stored at ambient temperatures, 5 and 7 day samples at 0 degrees C).
• Subjects:
  Accidents, Occupational Dust Epidemiology Immune System Lung Mining Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Silicon Dioxide

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• Keywords:
  Air-monitoring Air-sampling-equipment Analytical-instruments Analytical-methods Chemical-analysis Quantitative-analysis
• Document Type:
  Text
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DPSE - Division of Physical Sciences and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-41
• NIOSHTIC Number:
  nn:00122119
• Citation:
  NIOSH 1980 Jan; :1-41
• CAS Registry Number:
  Acetone cyanohydrin (CAS RN 75-86-5)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, Division of Physical Sciences and Engineering, Cincinnati, Ohio, 41 pages, 16 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0eee05bc785d00fda78ca076cee699b5ada373d864c1aec972946f0f4d5727f48800d760183448f9f798919c96e3b5c5f9d4ee11b9880be871e001c54f0902f7
• Download URL:
  https://stacks.cdc.gov/view/cdc/179425/cdc_179425_DS1.pdf
• File Type:
  [PDF - 2.24 MB ]