Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Playford, Elliott G. ; McCall, Brad ; Smith, Greg ; Slinko, Vicki ; Allen, George ; ... More +
Playford, Elliott G. ; McCall, Brad ; Smith, Greg ; Slinko, Vicki ; Allen, George ; Smith, Ina ; Moore, Frederick ; Taylor, Carmel ; Kung, Yu-Hsin ; Field, Hume ; Less -
Description:
A recent Hendra virus outbreak at a veterinary clinic in Brisbane, Queensland, Australia, involved 5 equine and 2 human infections. In contrast to previous outbreaks, infected horses had predominantly encephalitic, rather than respiratory, signs. After an incubation period of 9-16 days, influenza-like illnesses developed in the 2 persons before progressing to encephalitis; 1 died. Both patients were given ribavirin. Basal serum and cerebrospinal fluid levels were 10-13 mg/L after intravenous administration and 6 mg/L after oral administration (isolate 90% inhibitory concentration 64 mg/L). Both patients were exposed to infected horses, 1 during the late incubation period in a horse. The attack rate for veterinary clinic staff exposed to infected horses was 10%. An isolate from this outbreak showed genetic heterogeneity with isolates from a concurrent, but geographically remote, outbreak and from previous outbreaks. Emergence of Hendra virus is a serious medical, veterinary, and public health challenge.
Subject:
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Adult
Animals
Australia
Contact Tracing
Disease Outbreaks
Encephalitis
Equines
Fatal Outcome
Female
Hendra Virus
Henipavirus
Henipavirus Infections
Horse Diseases
Horses
Humans
Male
Paramyxoviridae
Queensland
Research
Ribavirin
Viruses
Young Adult
Research

Source:
Emerg Infect Dis. 16(2):219-223.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c942a20b56be532d1c9e5aac3a6c17ec91d69f9b72cc4ec2d3f02958c8434638
File Type:

Supporting Files

• 	license.txt	txt
  	09-0552-F1.gif	gif
  	09-0552-F1.jpg	jpeg
  	09-0552-F2.gif	gif
  	09-0552-F2.jpg	jpeg
  	09-0552_appT-s1.pdf	pdf
  	09-0552_finalR.nxml	txt

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