Neurological and behavioral toxicology of increased lead absorption.

Details

• Personal Author:
  Baloh R
• Description:
  Neurologic symptoms, illustrated by three case histories, play a prominent part in acute lead (7439921) poisoning and growing evidence suggests an etiologic role of chronic increased lead absorption in several chronic neurologic diseases. A type of motor neuron disease characterized by symmetrical distal muscle wasting, slow progression, and a history of extensive exposure to lead was reported. Although response to chelation therapy was inconclusive, a therapeutic trial of chelation in any patient with motor neuron disease and history of major lead exposure was recommended. Delayed nerve conduction was demonstrated in guinea pigs slowly poisoned with lead acetate (301042), and subsequently, electrophysiologic abnormalities were found in asymtomatic lead workers. Because of these and other similar findings, neurologists and behavioralists are questioning the adequacy of present standards of safe lead absorption.
• Subjects:
  Accidents, Occupational Laboratories Occupational Health Personal Protective Equipment Quality Control Respiratory Protective Devices Safety
• Keywords:
  Age-factors Behavior Chronic-toxicity Contract-210-75-0026 Heavy-metals Mental-processes Nervous-system-disorders Neuromotor-disorders NIOSH-Author NIOSH-Contract Toxicology

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• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Illinois ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  51-57
• NIOSHTIC Number:
  nn:00056273
• Citation:
  Health effects of occupational lead and arsenic exposure, a symposium, Carnow BW, ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-134, 1976 Feb; :51-57
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead diacetate (CAS RN 301-04-2)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a784fda3a8f0ee1978344007f28f7acc391ddc9bda34f96f4a5ec062e37d5dc3b4fd269e85c9f13b031705466f473d4e27890851a4332cad7a2afaa56cbf78c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/178759/cdc_178759_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]