Experimentally produced osteonecrosis as a result of fat embolism.

Details

• Personal Author:
  Anderson CE ; Jones JP Jr. ; Sakovich L
• Description:
  Experimental studies on rabbits were made to test the hypothesis that fat embolism of bone may be an initiating event in producing osteonecrosis. Focal and minute regions of avascular necrosis in bone and marrow were produced in the metaphyseal and epiphyseal zones of the right femoral heads of rabbits by a single infusion of .12 milliliters of Lipiodol (iodized oil) into the distal aorta. Fat emboli persisted up to five weeks after infusion. The presence of osteonecrosis was determined by roentgenographic, histologic, and radioautographic methods. Slightly increased bone density of questionable significance was observed at six and ten weeks after infusion. It is speculated that the etiological agent in dysbaric osteonecrosis may not be reversible with decompression therapy alone, but may also require the use of various lipid-clearing agents.
• Subjects:
  Accident Prevention Accidents Accidents, Occupational Agriculture Epidemiology Farmers Mortality Occupational Health Safety
• Keywords:
  Blood-disorders Bone-disorders Circulatory-system-disorders Clots Decompression-sickness Musculoskeletal-system-disorders Skeletal-system-disorders
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  117-132
• NIOSHTIC Number:
  nn:00053643
• Citation:
  Dysbarism-related osteonecrosis: proceedings of a symposium on dysbaric osteonecrosis. Beckman EL, Elliott DH, eds. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 75-153, 1974 Jan; :117-132
• Editor(s):
  Beckman EL ; Elliott DH
• Federal Fiscal Year:
  1974
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:49429aff098baccbaf1400a04ff958afefcdde751c3a546a9c6f1b44a1464fc2056aba36ad8ec4571ee1337f1f28b8bdd84c89a56e1cc27d141c79f6b33a54bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/178707/cdc_178707_DS1.pdf
• File Type:
  [PDF - 2.86 MB ]