Blood Culture Contamination and Diagnostic Stewardship: From a Clinical Laboratory Quality Monitor to a National Patient Safety Measure

Details

• Alternative Title:
  J Appl Lab Med
• Personal Author:
  Bunn, Jake D. ; Cornish, Nancy E.
• Description:
  Laboratory analysis of blood cultures is vital to the accurate and timely diagnosis of bloodstream infections. However, the reliability of the test depends on clinical compliance with standard operating procedures that limit the risk of inconclusive or incorrect results. False-negative blood culture results due to inadequate volumes of blood can result in misdiagnosis, delay therapy, and increase patients' risk of developing or dying from bloodstream infections. Likewise, commonly occurring bacteria or fungi on human skin (i.e., commensal organisms) can contaminate the blood culture during collection and increase the risk of false positives, compromising care and leading to unnecessary antibiotic therapy and prolonged hospitalization. In December 2022, a Centers for Medicare & Medicaid Services (CMS) consensus-based entity (CBE) endorsed the Centers for Disease Control and Prevention's (CDC) proposal for a new patient safety measure to address these concerns. CDC developed this quality measure to promote the standardization of blood culture best practices and improve laboratory diagnosis of bloodstream infections nationally. This special report will emphasize the importance of standardizing blood culture collection and describe the need for a national patient safety measure, new quality tools, and next steps.
• Subjects:
  Blood Culture Centers For Disease Control And Prevention, U.S. Centers For Medicare And Medicaid Services, U.S. Humans Laboratories, Clinical Patient Safety Sepsis United States
• Source:
  J Appl Lab Med. 10(1):162-170
• Pubmed ID:
  39749452
• Pubmed Central ID:
  PMC11709119
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  10
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:03ad5c0cbdbbcddb7444cc14955c5e05a2e6b0209e6dd0694c02ea8c5e36d7d5b8315831ab7a7df0edbaa384a0dd45c744cbedbd38d8b2e6975d7575b12a51b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/175582/cdc_175582_DS1.pdf
• File Type:
  [PDF - 75.11 KB ]