Cardiovascular disease risk factors in congenital heart disease survivors are associated with heart failure

Details

• Alternative Title:
  Pediatr Res
• Personal Author:
  Landstrom, Andrew P. ; Spears, Tracy ; D’Ottavio, Alfred ; Chiswell, Karen ; Sommerhalter, Kristin ; Soim, Aida ; Farr, Sherry L. ; Crume, Tessa ; Book, Wendy M. ; Whitehead, Kevin ; Botto, Lorenzo D. ; Li, Jennifer S. ; Hsu, Daphne T.
• Description:
  BACKGROUND:
  
  Despite advances in treatment and survival, individuals with congenital heart defects (CHD) have a higher risk of heart failure (HF) compared to the general population.
  
  OBJECTIVE:
  
  To evaluate comorbidities associated with HF in patients with CHD with a goal of identifying potentially modifiable risk factors that may reduce HF-associated morbidity and mortality.
  
  METHODS:
  
  Five surveillance sites in the United States linked population-based healthcare data and vital records. Individuals with an ICD-9-CM code for CHD aged 11–64 years were included and were stratified by presence of HF diagnosis code. Prevalence of death and cardiovascular risk factors based on diagnosis codes were compared by HF status using log-linear regression.
  
  RESULTS:
  
  A total of 25,343 individuals met inclusion/exclusion criteria. HF was documented for 2.2% of adolescents and 12.9% of adults with CHD. Adolescents and adults with HF had a higher mortality than those without HF. In both age groups, HF was positively associated with coronary artery disease, hypertension, obesity, diabetes, and increased healthcare utilization compared to those without HF.
  
  CONCLUSIONS:
  
  Within this population-based cohort, over 1 in 50 adolescents and 1 in 8 adults with CHD had HF, which was associated with increased mortality. Modifiable cardiovascular comorbidities were associated with HF.
  
  
• Source:
  Pediatr Res.
• Pubmed ID:
  38969815
• Pubmed Central ID:
  PMC11700225
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 HL160654/HL/NHLBI NIH HHSUnited States/ ; R01 HL166217/HL/NHLBI NIH HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a6d9ce2c9d490f5b86a7a0b462a7b4282f33831670fdae0673bbc0d999d013fbff82d8db22352978d21ccea7f2ab07310d858a627b45315ed40267253ed369aa
• File Type: