Fine-grained Patient Similarity Measuring using Contrastive Graph Similarity Networks

Details

• Alternative Title:
  Proc (IEEE Int Conf Healthc Inform)
• Personal Author:
  Liu, Yuxi ; Zhang, Zhenhao ; Qin, Shaowen ; Salim, Flora D. ; Bian, Jiang ; Jimeno Yepes, Antonio
• Description:
  Predictive analytics using Electronic Health Records (EHRs) have become an active research area in recent years, especially with the development of deep learning techniques. A popular EHR data analysis paradigm in deep learning is patient representation learning, which aims to learn a condensed mathematical representation of individual patients. However, EHR data are often inherently irregular, i.e., data entries were captured at different times as well as with different contents due to the individualized needs of each patient. Most of the work focused on the provision of deep neural networks with attention mechanisms that generate complete patient representations that can be readily used for downstream prediction tasks. However, such approaches fail to take patient similarity into account, which is generally used in clinical reasoning scenarios. This study presents a new Contrastive Graph Similarity Network for similarity calculation among patients in large EHR datasets. Particularly, we apply graph-based similarity analysis that explicitly extracts the clinical characteristics of each patient and aggregates the information of similar patients to generate rich patient representations. Experimental results on real-world EHR databases demonstrate the effectiveness and superiority of our method for the task of vital signs imputation and ICU patient deterioration prediction.
• Keywords:
  Graph Contrastive Learning Patient Representation Learning Patient Similarity Calculation
• Source:
  Proc (IEEE Int Conf Healthc Inform). 2024:1-10
• Pubmed ID:
  39698046
• Pubmed Central ID:
  PMC11654828
• Document Type:
  Journal Article
• Funding:
  R01 AG084236/AG/NIA NIH HHSUnited States/ ; U18 DP006512/DP/NCCDPHP CDC HHSUnited States/ ; RF1 AG084178/AG/NIA NIH HHSUnited States/ ; R01 AG080624/AG/NIA NIH HHSUnited States/ ; R01 AG083039/AG/NIA NIH HHSUnited States/ ; R01 AI172875/AI/NIAID NIH HHSUnited States/ ; UL1 TR001427/TR/NCATS NIH HHSUnited States/
• Volume:
  2024
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:044d0f77e1d085a3144f0462b09beca200b43adeed04ed20f3427ecee480b06f3815cca866d5a5af6399804ebfe9370a7da427da935109309dc42a2ba2a9609a
• Download URL:
  https://stacks.cdc.gov/view/cdc/175230/cdc_175230_DS1.pdf
• File Type:
  [PDF - 1.57 MB ]