Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Burman, William J. ; Bliven, Erin E. ; Cowan, Lauren ; Bozeman, Lorna ; Nahid, Payam ; ... More +
Burman, William J. ; Bliven, Erin E. ; Cowan, Lauren ; Bozeman, Lorna ; Nahid, Payam ; Diem, Lois ; Vernon, Andrew Less -
Corporate Authors:
Tuberculosis Trials Consortium
Description:
The role of microbial factors in outcomes of tuberculosis treatment has not been well studied. We performed a case-control study to evaluate the association between a Beijing strain and tuberculosis treatment outcomes. Isolates from patients with culture-positive treatment failure (n = 8) or relapse (n = 54) were compared with isolates from randomly selected controls (n = 296) by using spoligotyping. Patients with Beijing strains had a higher risk for relapse (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.0-4.0, p = 0.04) but not for treatment failure. Adjustment for factors previously associated with relapse had little effect on the association between Beijing strains and relapse. Beijing strains were strongly associated with relapse among Asian-Pacific Islanders (OR 11, 95% CI 1.1-108, p = 0.04). Active disease caused by a Beijing strain was associated with increased risk for relapse, particularly among Asian-Pacific Islanders.
Subject:
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Antibiotics, Antitubercular
Antitubercular Agents
Asian Continental Ancestry Group
Case-Control Studies
HIV Infections
Humans
Recurrence
Research
Rifampin
Risk Factors
Treatment Failure
Treatment Outcome
Tuberculosis
Tuberculosis, Pulmonary

Source:
Emerg Infect Dis. 15(7):1061-1067.
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a985ac211605edfb824543036d467e2c49878b60826fdc84b415b8783cb768da
File Type:

Supporting Files

• 	08-1253-F.gif	gif
  	08-1253-F.jpg	jpeg
  	08-1253_finalR.nxml	txt
  	license.txt	txt

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