Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Sintasath, David M.; Wolfe, Nathan D.; LeBreton, Matthew.; Jia, Hongwei.; Garcia, Albert D.; ... More +
Sintasath, David M.; Wolfe, Nathan D.; LeBreton, Matthew.; Jia, Hongwei.; Garcia, Albert D.; Diffo, Joseph Le Doux.; Tamoufe, Ubald.; Carr, Jean K.; Folks, Thomas M.; Mpoudi-Ngole, Eitel.; Burke, Donald S.; Heneine, Walid.; Switzer, William M.; Less -
Description:
Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.
Subject:
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Animals
Animals, Wild
Blood Specimen Collection
Cercopithecidae
Deltaretrovirus Infections
Genetic Variation
Humans
Meat
Monkey Diseases
Polymerase Chain Reaction
Primate T-lymphotropic Virus 3
Research
Sequence Analysis, DNA
Simian T-lymphotropic Virus 1
Strepsirhini

Source:
Emerg Infect Dis. 15(2):175-184.;
Document Type:
Journal Article;
Place as Subject:
Cameroon;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8ba5aed323226e90ba86d7e56f22e3c5bf32537df808a96f33caf54e78c87d03
File Type:

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