Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon

Sintasath, David M.; Wolfe, Nathan D.; LeBreton, Matthew.; Jia, Hongwei.; Garcia, Albert D.; Diffo, Joseph Le Doux.; Tamoufe, Ubald.; Carr, Jean K.; Folks, Thomas M.; Mpoudi-Ngole, Eitel.; Burke, Donald S.; Heneine, Walid.; Switzer, William M.

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Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon

Supporting Files Public Domain

Feb 2009
By Sintasath, David M. ; Wolfe, Nathan D. ; LeBreton, Matthew. ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Sintasath, David M. ; Wolfe, Nathan D. ; LeBreton, Matthew. ; Jia, Hongwei. ; Garcia, Albert D. ; Diffo, Joseph Le Doux. ; Tamoufe, Ubald. ; Carr, Jean K. ; Folks, Thomas M. ; Mpoudi-Ngole, Eitel. ; Burke, Donald S. ; Heneine, Walid. ; Switzer, William M.
Description:

Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.
Subjects:

Animals Animals, Wild Blood Specimen Collection Cercopithecidae Deltaretrovirus Infections Genetic Variation Humans Meat Monkey Diseases Polymerase Chain Reaction Primate T-lymphotropic Virus 3 Research Sequence Analysis, DNA Simian T-lymphotropic Virus 1 Strepsirhini
Source:

Emerg Infect Dis. 15(2):175-184.
Document Type:

Journal Article
Place as Subject:

Cameroon
Location:

Africa
Volume:

15
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:8ba5aed323226e90ba86d7e56f22e3c5bf32537df808a96f33caf54e78c87d03
Download URL:

https://stacks.cdc.gov/view/cdc/17310/cdc_17310_DS1.pdf
File Type:

[PDF - 274.82 KB ]

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