Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon

Sintasath, David M.; Wolfe, Nathan D.; LeBreton, Matthew.; Jia, Hongwei.; Garcia, Albert D.; Diffo, Joseph Le Doux.; Tamoufe, Ubald.; Carr, Jean K.; Folks, Thomas M.; Mpoudi-Ngole, Eitel.; Burke, Donald S.; Heneine, Walid.; Switzer, William M.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon

Published Date:

Feb 2009

Source:

Emerg Infect Dis. 15(2):175-184.

[PDF-274.82 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Sintasath, David M. ; Wolfe, Nathan D. ; LeBreton, Matthew. ; Jia, Hongwei. ; Garcia, Albert D. ; ... More ▼

Description:

Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.

Subject:

[+]

Document Type:

Journal Article

Place as Subject:

Cameroon

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	08-0584-F5.gif	image/gif
	08-0584-F5.jpg	image/jpeg
	08-0584-F6.gif	image/gif
	08-0584-F6.jpg	image/jpeg
	08-0584_finalR.nxml	text/plain
	license.txt	text/plain
	08-0584-F1.gif	image/gif
	08-0584-F1.jpg	image/jpeg
	08-0584-F2.gif	image/gif
	08-0584-F2.jpg	image/jpeg
	08-0584-F3.gif	image/gif
	08-0584-F3.jpg	image/jpeg
	08-0584-F4.gif	image/gif
	08-0584-F4.jpg	image/jpeg

No Related Documents.

You May Also Like:

Simian Foamy Virus Transmission from Apes to Humans, Rural Cameroon

Personal Author:

Calattini, Sara; Betsem, Edouard B.A.; Froment, Alain; Mauclère, Philippe; Tortevoye, Patricia; Schmitt, Christine; Njouom, Richard; Saib, Ali; Gessain, Antoine;

Published Date:

Sep 2007

Source:

Emerg Infect Dis. 13(9):1314-1320.

Description:

Simian virus infections of humans are an increasing public health concern. Simian foamy virus (SFV) infections have been reported in persons occupationally exposed to nonhuman primates and in a few hunters in Cameroon. To better understand this retro...

File Type:

[PDF - 275.41 KB]
Origin of Human T-Lymphotropic Virus Type 1 in Rural Côte d’Ivoire

Personal Author:

Calvignac-Spencer, Sébastien; Adjogoua, Edgard V.; Akoua-Koffi, Chantal; Hedemann, Claudia; Schubert, Grit; Ellerbrok, Heinz; Leendertz, Siv Aina Jensen; Pauli, Georg; Leendertz, Fabian H.;

Published Date:

May 2012

Source:

Emerg Infect Dis. 18(5):830-833.

Description:

Simian T-lymphotropic virus type 1 (STLV-1) strains occasionally infect humans. However, the frequency of such infections is unknown. We show that direct transmission of STLV-1 from nonhuman primates to humans may be responsible for a substantial pro...

File Type:

[PDF - 245.96 KB]
A gorilla reservoir for human T-lymphotropic virus type 4

Personal Author:

LeBreton, Matthew; Switzer, William M.; Djoko, Cyrille F.; Gillis, Amethyst; Jia, Hongwei; Sturgeon, Michele M.; Shankar, Anupama; Zheng, Haoqiang; Nkeunen, Gerard; Tamoufe, Ubald; Nana, Ahmadou; Le Doux Diffo, Joseph; Tafon, Babila; Kiyang, John; Schneider, Bradley S.; Burke, Donald S.; Wolfe, Nathan D.;

Published Date:

Jan 2014

Source:

Emerg Microbes Infect. 2014; 3(1):e7-.

Description:

Of the seven known species of human retroviruses only one, human T-cell lymphotropic virus type 4 (HTLV-4), lacks a known animal reservoir. We report the largest screening for simian T-cell lymphotropic virus (STLV-4) to date in a wide range of capti...

File Type:

[PDF - 2.63 MB]
Dual Simian Foamy Virus/Human Immunodeficiency Virus Type 1 Infections in Persons from Côte d’Ivoire

Personal Author:

Switzer, William M.; Tang, Shaohua; Zheng, HaoQiang; Shankar, Anupama; Sprinkle, Patrick S.; Sullivan, Vickie; Granade, Timothy C.; Heneine, Walid;

Published Date:

Jun 16 2016

Source:

PLoS One. 11(6).

Description:

Zoonotic transmission of simian retroviruses in West-Central Africa occurring in primate hunters has resulted in pandemic spread of human immunodeficiency viruses (HIVs) and human T-lymphotropic viruses (HTLVs). While simian foamy virus (SFV) and sim...

File Type:

[PDF - 2.62 MB]
Novel Multiplexed HIV/Simian Immunodeficiency Virus Antibody Detection Assay

Personal Author:

Ahuka-Mundeke, Steve; Ayouba, Ahidjo; Mbala-Kingebeni, Placide; Liegeois, Florian; Esteban, Amandine; Lunguya-Metila, Octavie; Demba, Didace; Bilulu, Guy; Mbenzo-Abokome, Valentin; Inogwabini, Bila-Isia; Muyembe-Tamfum, Jean-Jacques; Delaporte, Eric; Peeters, Martine;

Published Date:

Dec 2011

Source:

Emerg Infect Dis. 17(12):2277-2286.

Description:

Like most emerging infectious disease viruses, HIV is also of zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collec...

File Type:

[PDF - 417.95 KB]