Health Hazard Evaluation Report: HETA-82-257-1571: Manufacturing Chemists, Inc.; Indianapolis, Indiana

Details

• Personal Author:
  Aw, Tar-Ching ; Glueck, Charles J. ; Smith, Alexander B. ; Stephenson, Richard L.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Environmental and breathing zone samples were analyzed for zeranol (26538443) at Manufacturing Chemists, Incorporated (SIC-2879, SIC- requested by the State Industrial Hygiene Compliance Section to assist in evaluating the occurrence of breast symptoms, weight gain, and gynecomastia in employees and their children. Questionnaire interviews were conducted with 11 workers (5 males) and 14 comparisons (8 males). Clinical breast examinations were given to the males. Blood samples were analyzed for zeranol metabolites. Breathing zone zeranol concentrations ranged from 4.1 to 1,554 micrograms per cubic meter
  
  dermal samples contained up to 90 milligrams (mg). Wipe samples showed zeranol concentrations up to 14mg per sample. A sample of work clothing routinely laundered at home contained 16mg of zeranol. There is no current Federal standard for zeranol. Exposed workers reported a higher, though statistically insignificant, prevalence of breast symptoms than comparisons. No evidence of distinct subaureolar masses was found in male subjects. No zeranol metabolites were found in blood samples. The authors conclude that workers have a considerable exposure to zeranol which poses a potential health risk. Recommendations include improving engineering controls and not allowing employees to take work clothing home.
  
  
• Subjects:
  Animals Chemistry Chemistry, Analytic Chromatography Gynecomastia Occupational Health Safety
• Keywords:
  Agricultural Chemicals Anabolic Agent Analytical-chemistry Analytical-instruments Animal-products Chromatographic-analysis Estradiol Estrogen Growth-Promoter Hazards-Confirmed HETA-82-257-1571 Livestock Products NIOSH-Author NIOSH-Health-Hazard-Evaluation NIOSH-Technical-Assistance-Report OSHA Region 5 Ralgro Research Zearalenone Zeranol

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• Series:
  Health Hazard Evaluation Reports (HHE)
• Subseries:
  Health Evaluation and Technical Assistance (HETA)
• DOI:
  https://doi.org/10.26616/NIOSHHETA822571571
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Field Study
• Place as Subject:
  Indiana ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  48 pdf pages
• Contributor:
  Osimbowale, Abraham ; Collins, James ; Boiano, James ; King, Michael V. ; Glueck, Charles J. ; Menzies, Ken ; Phipps, Frederick C. ; Belinky, Barry R. ; Neumeister, Charles ; Johnson, Patty ; Frey, Tony ; Jolliffe, Lynette ; Conway, Kathy
• NIOSHTIC Number:
  nn:00152217
• NTIS Accession Number:
  PB86-117561
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 82-257-1571, 1985 Mar ; :1-47
• CAS Registry Number:
  Zeranol (CAS RN 26538-44-3)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  2879 - Agricultural chemicals, not elsewhere classified - (SIC) ; 0219 - General livestock, not elsewhere classified - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e7d857094c753fa398d342a65d172b566f51b6bd976ddb967b826ac5cd1be987652b9c58f567b88d16d1e7f0648e75aec76645daea90afc21f06d2691e88ce61
• Download URL:
  https://stacks.cdc.gov/view/cdc/172291/cdc_172291_DS1.pdf
• File Type:
  [PDF - 4.76 MB ]