Health Hazard Evaluation Report: HETA-81-385-1659: Texaco Chemical Company; Port Neches, Texas

Details

• Personal Author:
  Meinhardt, Theodore J.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Following a request made by the Oil, Chemical and Atomic Workers Union, genotoxicity associated with occupational exposures to ethylene-oxide (75218) at the Texaco Chemical Company (SIC-2810), Port Neches, Texas, was evaluated. Blood and industrial hygiene samples were collected. The annual mean exposure to ethylene-oxide in the production departments had been 1.73 parts per million (ppm) or less during the period from 1978 through 1982 with short-term peak exposures over 100ppm. Analyses of the chromosomal aberrations (CA) and sister chromatid exchange (SCE) data suggest that the exposures appear to produce marginally significant increases in the group mean SCE frequency per chromosome per cell in nonsmokers compared to control nonsmokers. The author concludes that these exposures are not associated with an overwhelming increase in genotoxicity effect. Significant elevations observed in both the group mean SCE frequency per chromosome per cell and in group mean transformed CA frequency of lab workers compared to those frequencies observed in referents cannot be attributed solely to ethylene-oxide due to the complex nature of this working environment. As a potential occupational carcinogen, exposure to ethylene oxide is to be reduced to the lowest extent possible.
• Subjects:
  Carcinogens Chromosomes Ethylenes Genetics Manufacturing And Industrial Facilities Mutagens Occupational Health Safety
• Keywords:
  Chemical-manufacturing-industry Chemical Manufacturing Chemical Workers Chromosomal Aberrations Chromosome-disorders Ethylene Oxide Genetic-disorders Genotoxicity Hazard-Unconfirmed HETA-81-385-1659 Laboratory Workers NIOSH-Health-Hazard-Evaluation NIOSH-Publication NIOSH-Technical-Assistance-Report OSHA Region 6 Oxides Sister Chromatid Exchange

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• Series:
  Health Hazard Evaluation Reports (HHE)
• Subseries:
  Health Evaluation and Technical Assistance (HETA)
• DOI:
  https://doi.org/10.26616/NIOSHHETA813851659
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Field Study
• Place as Subject:
  Texas ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  20 pdf pages
• Contributor:
  Beck, Nancy ; Graydon, Janet
• NIOSHTIC Number:
  nn:00163147
• NTIS Accession Number:
  PB86-221579
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 81-385-1659, 1986 Feb ; :1-17
• CAS Registry Number:
  Ethylene oxide (CAS RN 75-21-8)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  281 - Industrial Inorganic Chemicals - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a02e99feff5cd2fe08c370a649938a58450372d2d73c1f7eaefe33961233264cde54c9baedd633bbb6025928eb9c6283900a6537fef0dba6a1a4911d265987de
• Download URL:
  https://stacks.cdc.gov/view/cdc/172210/cdc_172210_DS1.pdf
• File Type:
  [PDF - 4.79 MB ]