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Fresno, California
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1984/05/01
[PDF-1.85 MB]
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Description:In response to a request for assistance from the California State Department of Industrial Relations, Division of Occupational Safety and Health, a new method developed for estimating cholinesterase inhibition in pesticide applicators (SIC-0721) was evaluated. A study was designed to determine whether quantitative determinations could be made of organophosphate exposure by determining the ratio of serum cholinesterase activity to the amount of total butyrylcholinesterase (BCHE) protein determined by immunodiffusion. If this method were successful it would eliminate the problems caused by individual differences in BCHE levels and also allow an estimate of BCHE inhibition to be made in individuals for whom a preexposure baseline BCHE measurement does not exist. Serum was obtained from healthy volunteers and then spiked in-vitro with either dichlorvos (62737) (DDVP) or paraoxon (311455). Measurements were also taken of cholinesterase activity among pesticide applicators. The degree of inhibition of samples treated in-vitro with paraoxon or DDVP was very well correlated with the ratio of serum cholinesterase activity/enzyme protein measured immunologically. The authors conclude that immunoassay of cholinesterase can detect organophosphate poisoned protein. The authors recommend that further testing of this method using sera from severely cholinesterase inhibited individuals be carried out.
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Pages in Document:11 pdf pages
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Contributor:Luciano, Nancy A.;La Du, Bert N.;Lewis, Ann;
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NIOSHTIC Number:nn:00179024
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NTIS Accession Number:PB85-184265
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Citation:Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 82-248-1472, 1984 May;:1-11;
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Federal Fiscal Year:1984
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Peer Reviewed:False
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