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Health Hazard Evaluation Report: HETA-83-422-L1965: Department of Energy, Martin Marietta Energy Systems, Inc.; Health Evaluation of Y-12 Workers Formerly Exposed to Mercury
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1987/05/01
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Description:The possibility that a relationship existed between occupational mercury (7439976) exposure at the Y-12 facility, Department of Energy, Martin Marietta Energy Systems, Inc., and persistent health effects. The cohort of workers studied included those whose work experience lasted at least 4 months at the Y-12 facility between 1953 and 1966. Only two significant differences were noted after the data was analyzed between mercury exposed and comparison groups: decreased proximal strength and sensory median amplitude. These differences were small in magnitude and lacking in clinical meaning. In the dose/response analyses, 11 of the almost 60 clinical, quantitative and electrodiagnostic variables were weakly and significantly related to either integrated or peak urine mercury exposures. Each of the 11 demonstrated abnormalities in the mercury exposed group. Their findings, however, were not sufficient to conclude that prior mercury exposure was associated with a chronic sensorimotor peripheral polyneuropathy. Subjects with urine mercury levels above 0.6 milligrams/liter demonstrated slightly poorer performance than the remaining subjects including decreased strength, decreased coordination, increased tremor, decreased sensation, and increased prevalence of Babinski and snout reflexes which were consistent with small, subclinical central and peripheral nervous system adverse effects. For the vast majority of subjects there was no evidence of a definite tremor, no adverse reproductive outcome, and no evidence of a dose response relationship between any cognitive measures and exposure measures.
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Pages in Document:244 pdf pages
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NIOSHTIC Number:00190275
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NTIS Accession Number:PB90-119918
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Citation:Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 83-422-L1965, 1987 May; :1-235
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Federal Fiscal Year:1987
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Peer Reviewed:False
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Resource Number:HETA-83-422-L1965
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[PDF-10.86 MB]