Health Hazard Evaluation Report: HETA-91-104-2229: Florida Hospital; Orlando, Florida

Details

• Personal Author:
  Decker, John A. ; Shults, Ruth A.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In response to a request by hospital management to evaluate employee exposures to aerosolized ribavirin (36791045) (Arkansas), an investigation was made at Florida Hospital (SIC-8062), Orlando, Florida. The hospital was an 801 bed medical center and teaching hospital. The investigation was conducted in the pediatric intensive care unit where Arkansas was administered to infants and children. An aerosol containment device was used on most administrations of Arkansas, and most health care workers used personal protective equipment as required by hospital policy. Urine samples (148) were collected from 44 health care workers and analyzed for ribavirin. Post shift urinary ribavirin concentrations equal to or above the limit of quantification of 0.01 micromole of ribavirin per liter of urine were found in 13 of 20 post shift urine samples from nurses and in three of 20 samples from respiratory therapists. Creatinine corrected post shift urinary ribavirin values ranged from less than mean of 0.017 micromole/gram. The mean post shift value for nurses was 0.030 micromole/gram while the mean for RTs was 0.004 micromole/gram.
• Subjects:
  Biopharmaceutics Health Personnel Hospitals Occupational Exposure Occupational Health Safety Urine
• Keywords:
  1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboximide Aerosol Containment System Aerosolized Drugs Aerosolized Pharmaceuticals Biological-monitoring General Medical And Surgical Hospitals Hazard-Confirmed Health-care-personnel Health Care Workers HETA-91-104-2229 NIOSH-Author NIOSH-Health-Hazard-Evaluation NIOSH-Technical-Assistance-Report Nursing Occupational-exposure OSHA Region 4 Pharmaceuticals Ribavirin Urinalysis Urinary Ribavirin Virazole

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• Series:
  Health Hazard Evaluation Reports (HHE)
• Subseries:
  Health Evaluation and Technical Assistance (HETA)
• DOI:
  https://doi.org/10.26616/NIOSHHETA911042229
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Field Study
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  43 pdf pages
• Contributor:
  Connor, James ; Deitchman, Scott D. ; Teass, Alexander W. ; Wild, Deanna K.
• NIOSHTIC Number:
  nn:00210229
• NTIS Accession Number:
  PB93-119345
• Citation:
  Cincinnati, Ohio: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 91-104-2229, 1992 Jun ; :1-48
• CAS Registry Number:
  Ribavirin (CAS RN 36791-04-5)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  8062 - General medical & surgical hospitals - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0f491e9dde4b6d2a3e7de1a3d5a77a1edbc99c66f0b4a4ad7da12e6ff4ab498f298cce79395adc387975f777025a5ac6540f53424581265bdce8a9e10d3ac1a
• Download URL:
  https://stacks.cdc.gov/view/cdc/171540/cdc_171540_DS1.pdf
• File Type:
  [PDF - 959.84 KB ]