Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Wongsrichanalai, Chansuda ; Meshnick, Steven R.
Wongsrichanalai, Chansuda ; Meshnick, Steven R. Less -
Description:
Resistance to many antimalaria drugs developed on the Cambodia-Thailand border long before developing elsewhere. Because antimalaria resistance is now a global problem, artemisinin-based combination therapies (ACTs) are the first-line therapies in most malaria-endemic countries. However, recent clinical and molecular studies suggest the emergence of ACT-resistant Plasmodium falciparum infections in the Cambodia-Thailand border area, where standard ACT is artesunate and mefloquine. These ACT failures might be caused by high-level mefloquine resistance because mefloquine was used for monotherapy long before the introduction of ACT. This observation raises 2 questions. First, how can existing P. falciparum-resistant strains be controlled? Second, how can the evolution of new ACT- resistant strains be avoided elsewhere, e.g., in Africa? Enforcement of rational drug use and improved diagnostic capacity are among the measures needed to avoid and contain ACT resistance.
Subject:
[+]
Animals
Antimalarials
Artemisinins
Directly Observed Therapy
Drug Resistance
Drug Therapy, Combination
Humans
Malaria, Falciparum
Mefloquine
Polymerase Chain Reaction
Synopsis
Treatment Failure

Source:
Emerg Infect Dis. 14(5):716-719.
Document Type:
Journal Article
Place as Subject:
Cambodia ; Thailand
Cambodia ; Thailand Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a56ecb5bd9df81122214a0ee99f6d2162b8d488b920f102723e98703e435187d
File Type:

Supporting Files

• 	07-1601-F.gif	gif
  	07-1601-F.jpg	jpeg
  	07-1601_finalS.nxml	txt
  	license.txt	txt

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