Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Wongsrichanalai, Chansuda ; Meshnick, Steven R.
Wongsrichanalai, Chansuda ; Meshnick, Steven R. Less -
Description:
Resistance to many antimalaria drugs developed on the Cambodia-Thailand border long before developing elsewhere. Because antimalaria resistance is now a global problem, artemisinin-based combination therapies (ACTs) are the first-line therapies in most malaria-endemic countries. However, recent clinical and molecular studies suggest the emergence of ACT-resistant Plasmodium falciparum infections in the Cambodia-Thailand border area, where standard ACT is artesunate and mefloquine. These ACT failures might be caused by high-level mefloquine resistance because mefloquine was used for monotherapy long before the introduction of ACT. This observation raises 2 questions. First, how can existing P. falciparum-resistant strains be controlled? Second, how can the evolution of new ACT- resistant strains be avoided elsewhere, e.g., in Africa? Enforcement of rational drug use and improved diagnostic capacity are among the measures needed to avoid and contain ACT resistance.
Subjects:
[+]
Animals Antimalarials Artemisinins Directly Observed Therapy Drug Resistance Drug Therapy, Combination Humans Malaria, Falciparum Mefloquine Polymerase Chain Reaction Synopsis Treatment Failure
Source:
Emerg Infect Dis. 14(5):716-719.
Document Type:
Journal Article
Place as Subject:
Cambodia ; Thailand
Cambodia ; Thailand Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a56ecb5bd9df81122214a0ee99f6d2162b8d488b920f102723e98703e435187d
Download URL:
https://stacks.cdc.gov/view/cdc/17148/cdc_17148_DS1.pdf
File Type:

Supporting Files

• 	07-1601-F.gif	gif
  	07-1601-F.jpg	jpeg
  	07-1601_finalS.nxml	txt
  	license.txt	txt

More +