Health Hazard Evaluation Report: HETA 90-0360-2504: Ciba-Geigy, McIntosh, Alabama

Details

• Personal Author:
  Grajewski, Barbara A. ; Whelan, Elizabeth A.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In response to a request from the Oil, Chemical, and Atomic Worker's International Union, and the local, an investigation was begun into reported impotence and decreased libido among male employees at Ciba- Geigy (SIC-81118), McIntosh, Alabama. Concern was voiced regarding exposure to the chemical intermediate 4,4'-diaminostilbene-2,2'- disulfonic-acid (81118) (DAS) and resulting impotence and decreased libido. A target population of 129 male workers was identified for study. Levels of six reproductive hormones in 30 male workers who manufactured DAS and 20 former DAS workers were compared to hormone levels of 35 workers who manufactured plastics additives in a different manufacturing area. Lower mean total testosterone (TT) levels were found in the current and former DAS workers compared to additives workers. In logistic regression analysis, current and former DAS workers were 3.6 and 2.2 times more likely than additives workers to have lowest quartile TT levels after adjusting for age and body mass index. A questionnaire was used to analyze perceived libido and potency in the same groups. Results suggested that working in the DAS manufacturing area may have had an effect on sexual function. The authors suggest that occupational exposure during DAS manufacturing may be associated with alterations in male reproductive hormone levels, and with sexual dysfunction. The authors recommend that exposure to chemicals in the DAS manufacturing process should be reduced to the lowest feasible concentration.
• Subjects:
  Endocrine System Occupational Exposure Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Amsonic Acid Cyclic Organic Crudes And Intermediates, And Organic Dyes And Pigments Hazard-Confirmed HETA-90-0360-2504 Hormone-activity Impotence Male Reproductive Hormones NIOSH-Author NIOSH-Health-Hazard-Evaluation NIOSH-Technical-Assistance-Report Occupational-exposure OSHA Region 4 Reproductive-hazards Reproductive-system-disorders Stilbene Manufacture Testosterone

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• Series:
  Health Hazard Evaluation Reports (HHE)
• Subseries:
  Health Evaluation and Technical Assistance (HETA)
• DOI:
  https://doi.org/10.26616/NIOSHHETA9003602504
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Field Study
• Place as Subject:
  Alabama ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39 pdf pages
• Contributor:
  Alderfer, Raymond ; Calvert, Geoffrey ; Hackl, Yona ; Rose, Ray ; Jenkins, Barbara ; Schutte, Robert ; Fourcroy, Jean ; Mouradian, Robert ; Mueller, Charles ; Kesner, James ; Wild, Deanna K. ; Materson, Kathy
• NIOSHTIC Number:
  nn:00228261
• NTIS Accession Number:
  PB95-267910
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 90-0360-2504, 1995 Mar ; :1-41
• CAS Registry Number:
  4,4'-Diaminostilbene-2,2'-disulfonic acid (CAS RN 81-11-8)
• Federal Fiscal Year:
  1995
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  2865 - Cyclic crudes and intermediates - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d95dfe017198288d1d5708da0818340ef817daedd88bd66793acffad07c06efe4c5bce3868657d59b3442d5ff94e9e9c3934534be79488eb9ce5f84d8ecda35a
• Download URL:
  https://stacks.cdc.gov/view/cdc/171266/cdc_171266_DS1.pdf
• File Type:
  [PDF - 673.21 KB ]