Health Hazard Evaluation Report: HETA 94–0072–2648: Gen Corp Automotive, Marion, Indiana

Details

• Personal Author:
  Reh, Beth D.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In response to a request from the United Rubber Workers Union, Local 466, an investigation was conducted at Gen Corp Automotive (SIC- 3061), Marion, Indiana. The Union expressed concern regarding employee exposures in all three departments at the facility, the rubber vehicle sealing area, the mix house, and the liquid composite molding area. On site sample collection was performed along with medical interviews, informal conversations with employees, and a review of records. High nitrosamine concentrations were measured in the vehicle sealing department. Concentration of nitrosamines were as high as 16.34 micrograms/cubic meter. A salt bath curing process was generating the nitrosamines, and a combination of insufficient local exhaust ventilation and exhaust reentering the work area was contributing to the buildup. No overexposures were noted for other compounds such as volatile organics and aromatic hydrocarbons. DNA adducts in peripheral white blood cells and excised DNA adducts in the urine were studied. A significant correlation was noted between having detectable concentrations of O6-methyldeoxyguanosine adducts in peripheral white blood cells, and the negative correlation between nitrosamine exposure and O6-alkylguanine-DNA- alkyltransferase activity. The author concludes that there was a health hazard from the presence of nitrosamines in this workplace and recommended steps including elimination of the source by reformulation of the rubber stock or redesign of the curing process.
• Subjects:
  Isocyanates Nitrogen Compounds Occupational Exposure Occupational Health Rubber Safety Volatile Organic Compounds
• Keywords:
  AGT DNA-adducts DNA Adducts Hazard-Confirmed HETA-94-0072-2648 Isocyanates MDI Methylene Diisocyanate Molded, Extruded, And Lathe-cut Mechanical Rubber Goods N7-methyldeoxyguanosine NDBA NDEA NDMA NDPA NIOSH-Author NIOSH-Health-Hazard-Evaluation NIOSH-Technical-Assistance-Report Nitro-compounds Nitrosamines Nitrosodibutylamine Nitrosodiethylamine Nitrosodimethylamine Nitrosodipropylamine Nitrosomorpholine Nitrosopiperidine Nitrosopyrrolidine NMOR NPIP NPYR O6-alkylguanine-DNA Alkyltransferase O6-methyldeoxyguanosine Occupational-exposure OSHA Region 5 Rubber Rubber-workers Rubber Vehicle Sealing Sheet Molding Compound VOCs Volatile Organic Compounds

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• Series:
  Health Hazard Evaluation Reports (HHE)
• Subseries:
  Health Evaluation and Technical Assistance (HETA)
• DOI:
  https://doi.org/10.26616/NIOSHHETA9400722648
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Field Study
• Place as Subject:
  Indiana ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  172 pdf pages
• Contributor:
  Fajen, John M. ; Mattorano, Dino A. ; Esswein, Eric J. ; Reh, Christopher M. ; Marlow, David A. ; Barsan, Michael E. ; Burr, Gregory A. ; Blade, Leo M. ; Booher, Donald E. ; Coleman, Marian E. ; Reid, Thomas M. ; Werren, Dwight ; Kawamoto, Melody M. ; Cooper, Charles M. ; DeBord, D. Gayle, Cheever, Kenneth L. ; Butler, Mary Ann ; Haussler, B.J. ; Wall, David K. ; Sieber, William K. ; Blythe, Ellen E.
• NIOSHTIC Number:
  nn:00240025
• NTIS Accession Number:
  PB98-126147
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 94-0072-2648, 1997 Aug ; :1-180
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  3061 - Mechanical rubber goods - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d8f3ab16936af11b0d7628bc6562fef426040dbf9fcf48a768f529a75ae4ed5e93ebb2bdb5e90e76dc1ac80fb92180c9454f19af2c921bc68b2ab77d5757ecaa
• Download URL:
  https://stacks.cdc.gov/view/cdc/171095/cdc_171095_DS1.pdf
• File Type:
  [PDF - 13.48 MB ]