Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders

Details

• Alternative Title:
  Biol Psychiatry
• Personal Author:
  Weis, Carissa N. ; Webb, E. Kate ; deRoon-Cassini, Terri A. ; Larson, Christine L.
• Description:
  The psychological trauma associated with events resulting in traumatic brain injury (TBI) is an important and frequently overlooked factor that may impede brain recovery and worsen mental health following TBI. Indeed, individuals with comorbid posttraumatic stress disorder (PTSD) and TBI have significantly poorer clinical outcomes than individuals with a sole diagnosis. Emotion dysregulation is a common factor leading to poor cognitive and affective outcomes following TBI. Here, we synthesize how acute postinjury molecular processes stemming from either physical or emotional trauma may adversely impact circuitry subserving emotion regulation and ultimately yield long-term system-level functional and structural changes that are common to TBI and PTSD. In the immediate aftermath of traumatic injury, glucocorticoids stimulate excess glutamatergic activity, particularly in prefrontal cortex-subcortical circuitry implicated in emotion regulation. In human neuroimaging work, assessing this same circuitry well after the acute injury, TBI and PTSD show similar impacts on prefrontal and subcortical connectivity and activation. These neural profiles indicate that emotion regulation may be a useful target for treatment and early intervention to prevent the adverse sequelae of TBI. Ultimately, the success of future TBI and PTSD early interventions depends on the fields' ability to address both the physical and emotional impact of physical injury.
• Subjects:
  Brain Injuries, Traumatic Comorbidity Emotions Humans Psychological Trauma Stress Disorders, Post-Traumatic
• Keywords:
  Glutamate HPA Axis Neuroimaging Postconcussion Syndrome Posttraumatic Stress Disorder Traumatic Brain Injury
• Source:
  Biol Psychiatry. 91(5):470-477
• Pubmed ID:
  34561028
• Pubmed Central ID:
  PMC8801541
• Document Type:
  Journal Article
• Funding:
  U24 DA041147/DA/NIDA NIH HHSUnited States/ ; R56 MH116656/MH/NIMH NIH HHSUnited States/ ; TL1 TR001437/TR/NCATS NIH HHSUnited States/ ; R01 MH124076/MH/NIMH NIH HHSUnited States/ ; R01 MH106574/MH/NIMH NIH HHSUnited States/ ; U01 CE002944/CE/NCIPC CDC HHSUnited States/ ; UL1 TR001436/TR/NCATS NIH HHSUnited States/
• Volume:
  91
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:39a82ee9d972ef4aac549f532a5a7bff6ad04b58e5de7ccd981d66ae3e31709a26a19d438bea9789ba0c18d4994a2d3af21525db07f049832f2626ce081e331a
• Download URL:
  https://stacks.cdc.gov/view/cdc/170008/cdc_170008_DS1.pdf
• File Type:
  [PDF - 603.78 KB ]