Chikungunya Fever in Travelers Returning to Europe from the Indian Ocean Region, 2006

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Panning, Marcus ; Grywna, Klaus ; van Esbroeck, Marjan ; Emmerich, Petra ; Drosten, Christian
• Description:
  Chikungunya fever has spread through several Indian Ocean islands and India, including popular travel destinations. To compare usefulness of diagnostic tests and to understand reasons for the magnitude and severity of an outbreak, we used 3 diagnostic methods to test 720 samples from 680 patients returning to Europe from the Indian Ocean region in 2006. Chikungunya infection was confirmed for 24.4% patients in the first half of the year and for 9.9% in the second half. Reverse transcription-PCR was positive for all samples taken up to day 4 after symptom onset. Immunofluorescence detected immunoglobulin (Ig) M on day 1 and IgG on day 2 for some patients, and in all patients from day 5 onward. Soon after onset of symptoms, patients had IgG and IgM and high viral loads (some >10(9) copies/mL plasma). These data will help healthcare providers select diagnostic tests for returning travelers.
• Subjects:
  Adolescent Adult Aged Alphavirus Infections Antibodies, Viral Arbovirus Diagnostics Chikungunya Chikungunya Virus Cross-Sectional Studies Dengue Female Humans Male Middle Aged Real-time RT-PCR Research Serology Travel Travelers

  More +
• Source:
  Emerg Infect Dis. 14(3):416-422.
• Document Type:
  Journal Article
• Place as Subject:
  Europe ; India ; Indian Ocean ; Indonesia ; Kenya
• Location:
  Europe ; Asia ; Africa
• Volume:
  14
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:c256021b3c910175919c1f408d63f981182b515ff0fab5d72db804b02b1d8711ebb342a81a1f6b0612f48adbb09dff9083389937f526fbd2ecc2583cad43a886
• Download URL:
  https://stacks.cdc.gov/view/cdc/16949/cdc_16949_DS1.pdf
• File Type:
  [PDF - 249.46 KB ]