Streptococcus pneumoniae Serotype 19A in Children, South Korea

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Choi, Eun Hwa ; Kim, So Hee ; Eun, Byung Wook ; Kim, Sun Jung ; Kim, Nam Hee ; Lee, Jina ; Lee, Hoan Jong
• Description:
  Despite the concern of replacement disease, notably by serotype 19A after 7-valent conjugate vaccine (PCV7) use, serotype 19A was increasingly recognized in Korean children before the introduction of PCV7. To understand the dynamics of serogroup 19 prevalence from 1991-2006, we serotyped 538 pediatric pneumococcal isolates. Serogroup 19 isolates (n = 126) were characterized by antimicrobial drug susceptibility, presence of mefA/ermB, and multilocus sequence typing. Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased. Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.
• Subjects:
  Anti-Bacterial Agents Bacterial Proteins Child Child, Preschool Drug Resistance, Multiple, Bacterial Humans Infant Infant, Newborn Membrane Proteins Microbial Sensitivity Tests Multilocus Sequence Typing Pneumococcal Conjugate Vaccine Pneumococcal Infections Prevalence Research Serotype 19A Serotyping Streptococcus Pneumoniae

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• Source:
  Emerg Infect Dis. 14(2):275-281.
• Document Type:
  Journal Article
• Place as Subject:
  Republic of Korea
• Location:
  Asia
• Volume:
  14
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d41162499f0b8a2e7a95b7dc967d8d7f195de534d7e01bf3d0f943ce8231724a
• Download URL:
  https://stacks.cdc.gov/view/cdc/16917/cdc_16917_DS1.pdf
• File Type:
  [PDF - 366.06 KB ]