Streptococcus pneumoniae Serotype 19A in Children, South Korea

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Choi, Eun Hwa ; Kim, So Hee ; Eun, Byung Wook ; Kim, Sun Jung ; Kim, Nam Hee ; Lee, Jina ; Lee, Hoan Jong
• Description:
  Despite the concern of replacement disease, notably by serotype 19A after 7-valent conjugate vaccine (PCV7) use, serotype 19A was increasingly recognized in Korean children before the introduction of PCV7. To understand the dynamics of serogroup 19 prevalence from 1991-2006, we serotyped 538 pediatric pneumococcal isolates. Serogroup 19 isolates (n = 126) were characterized by antimicrobial drug susceptibility, presence of mefA/ermB, and multilocus sequence typing. Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased. Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.
• Subjects:
  • Research
  • Streptococcus pneumoniae
  • serotype 19A
  • multilocus sequence typing
  • pneumococcal conjugate vaccine
  • research
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Child
  • Child, Preschool
  More +
• Source:
  Emerg Infect Dis. 14(2):275-281.
• Document Type:
  Journal Article
• Place as Subject:
  Republic of Korea
• Location:
  Asia
• Volume:
  14
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/16917/cdc_16917_DS1.pdf
• File Type:
  [PDF - 366.06 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d41162499f0b8a2e7a95b7dc967d8d7f195de534d7e01bf3d0f943ce8231724a