β-Herpesviruses in Febrile Children with Cancer

Yee-Guardino, Stephanie; Gowans, Kate; Yen-Lieberman, Belinda; Berk, Pamela; Kohn, Debra; Wang, Fu-Zhang; Danziger-Isakov, Lara; Sabella, Camille; Worley, Sarah; Pellett, Philip E.; Goldfarb, Johanna

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β-Herpesviruses in Febrile Children with Cancer

Published Date:

Apr 2008

Source:

Emerg Infect Dis. 14(4):579-585.

[PDF - 266.46 KB]

Details:

Personal Authors:

Yee-Guardino, Stephanie ; Gowans, Kate ; Yen-Lieberman, Belinda ; Berk, Pamela ; Kohn, Debra ; ... More ▼

Keywords:

[+]

Description:

We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B-positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B-positive children had mild "viral" illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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07-06512_appT.pdf	application/pdf
07-06512_finalR.nxml	text/plain
license.txt	text/plain

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