Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Yee-Guardino, Stephanie ; Gowans, Kate ; Yen-Lieberman, Belinda ; Berk, Pamela ; Kohn, Debra ; ... More +
Yee-Guardino, Stephanie ; Gowans, Kate ; Yen-Lieberman, Belinda ; Berk, Pamela ; Kohn, Debra ; Wang, Fu-Zhang ; Danziger-Isakov, Lara ; Sabella, Camille ; Worley, Sarah ; Pellett, Philip E. ; Goldfarb, Johanna Less -
Description:
We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B-positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B-positive children had mild "viral" illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer.
Subject:
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Adolescent
Adult
Betaherpesvirinae
Child
Child, Preschool
Cross-Sectional Studies
Cytomegalovirus
Female
Fever
Herpesviridae Infections
Human Herpesvirus 6
Human Herpesvirus 7
Humans
Immunocompromised Host
Infant
Male
Neoplasms
Neutropenia
Organ Transplantation
Pediatric Cancer Patients
Research
Roseolovirus
Viremia

Source:
Emerg Infect Dis. 14(4):579-585.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:5cd7c12b65193a169ca15c99b4b41624550e1fd1339c2b36f2f035f7da83e9cb
File Type:

Supporting Files

• 	07-06512-F.gif	gif
  	07-06512-F.jpg	jpeg
  	07-06512_appT.pdf	pdf
  	07-06512_finalR.nxml	txt
  	license.txt	txt

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