β-Herpesviruses in Febrile Children with Cancer

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Yee-Guardino, Stephanie ; Gowans, Kate ; Yen-Lieberman, Belinda ; Berk, Pamela ; Kohn, Debra ; Wang, Fu-Zhang ; Danziger-Isakov, Lara ; Sabella, Camille ; Worley, Sarah ; Pellett, Philip E. ; Goldfarb, Johanna
  More +
• Description:
  We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B-positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B-positive children had mild "viral" illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer.
• Subjects:
  • Research
  • Fever
  • neutropenia
  • cytomegalovirus
  • roseolovirus
  • human herpesvirus 6
  • human herpesvirus 7
  • pediatric cancer patients
  • research
  • Adolescent
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• Source:
  Emerg Infect Dis. 14(4):579-585.
• Document Type:
  Journal Article
• Volume:
  14
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/16873/cdc_16873_DS1.pdf
• File Type:
  [PDF - 266.46 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5cd7c12b65193a169ca15c99b4b41624550e1fd1339c2b36f2f035f7da83e9cb