β-Herpesviruses in Febrile Children with Cancer

Yee-Guardino, Stephanie; Gowans, Kate; Yen-Lieberman, Belinda; Berk, Pamela; Kohn, Debra; Wang, Fu-Zhang; Danziger-Isakov, Lara; Sabella, Camille; Worley, Sarah; Pellett, Philip E.; Goldfarb, Johanna

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

β-Herpesviruses in Febrile Children with Cancer

Published Date:

Apr 2008

Source:

Emerg Infect Dis. 14(4):579-585.

[PDF-266.46 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Yee-Guardino, Stephanie ; Gowans, Kate ; Yen-Lieberman, Belinda ; Berk, Pamela ; Kohn, Debra ; ... More ▼

Description:

We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B-positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B-positive children had mild "viral" illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	07-06512-F.gif	image/gif
	07-06512-F.jpg	image/jpeg
	07-06512_appT.pdf	application/pdf
	07-06512_finalR.nxml	text/plain
	license.txt	text/plain

No Related Documents.

You May Also Like:

CME ACTIVITY: β-Herpesviruses in Febrile Children with Cancer

Published Date:

Apr 2008

Source:

Emerg Infect Dis. 14(4):578.

File Type:

[PDF - 810.13 KB]
Control Measures Used during Lymphogranuloma Venereum Outbreak, Europe

Personal Author:

Timen, Aura; Hulscher, Marlies E.J.L.; Vos, Dieuwke; van de Laar, Marita J.W.; Fenton, Kevin A.; van Steenbergen, Jim E.; van der Meer, Jos W.M.; Grol, Richard P.T.M.;

Published Date:

Apr 2008

Source:

Emerg Infect Dis. 14(4):573-578.

Description:

To assess the response to the reemergence of lymphogranuloma venereum, we conducted a cross-sectional survey by administering a structured questionnaire to representatives from 26 European countries. Responses were received from 18 countries. The abi...

File Type:

[PDF - 183.23 KB]
Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1

Personal Author:

Ansari, Asad; Li, Shaobing; Abzug, Mark J.; Weinberg, Adriana;

Published Date:

Aug 2004

Source:

Emerg Infect Dis. 10(8):1450-1454.

Description:

The role and frequency of human herpesviruses (HHV)-6 and -7 in central nervous system (CNS) diseases of children are unclear. Cerebrospinal fluid samples from 245 pediatric patients (median age 43 days), submitted for evaluations of possible sepsis ...

File Type:

[PDF - 43.15 KB]
Human herpesvirus 6: An emerging pathogen.

Personal Author:

Campadelli-Fiume, G.; Mirandola, P.; Menotti, L.;

Published Date:

1999 May-Jun

Source:

Emerg Infect Dis. 5(3):353-366.

Description:

Infections with human herpesvirus 6 (HHV-6), a beta-herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. Primary infection with HHV-6B causes roseola infantum or exanthem subitum, a com...

File Type:

[PDF - 527.20 KB]
Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

Personal Author:

Chowdary, Tirumala K.; Cairns, Tina M.; Atanasiu, Doina; Cohen, Gary H.; Eisenberg, Roselyn J.; Heldwein, Ekaterina E.;

Published Date:

Jul 04 2010

Source:

Nat Struct Mol Biol. 17(7):882-888.

Description:

Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-mach...

File Type:

[PDF - 4.93 MB]