Epidemiology of Travel-Associated Dengue from 2007 to 2022: A GeoSentinel Analysis

Details

• Alternative Title:
  J Travel Med
• Personal Author:
  Duvignaud, Alexandre ; Stoney, Rhett J. ; Angelo, Kristina M. ; Chen, Lin H. ; Cattaneo, Paolo ; Motta, Leonardo ; Gobbi, Federico G. ; Bottieau, Emmanuel ; Bourque, Daniel L. ; Popescu, Corneliu P. ; Glans, Hedvig ; Asgeirsson, Hilmir ; Oliveira-Souto, Ines ; Vaughan, Stephen D. ; Amatya, Bhawana ; Norman, Francesca F. ; Waggoner, Jesse ; Diaz-Menendez, Marta ; Beadsworth, Michael ; Odolini, Silvia ; Camprubí-Ferrer, Daniel ; Epelboin, Loic ; Connor, Bradley A. ; Eperon, Gilles ; Schwartz, Eli ; Libman, Michael ; Malvy, Denis ; Hamer, Davidson H. ; Huits, Ralph
• Corporate Authors:
  GeoSentinel Network
• Description:
  Background
  
  Dengue is a leading cause of febrile illness among international travelers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travelers evaluated at GeoSentinel sites from 2007–2022.
  
  Methods
  
  We retrieved GeoSentinel records of dengue among travelers residing in non-endemic countries. We considered dengue confirmed when diagnosed by a positive DENV-specific RT-PCR, positive NS-1 antigen, and/or anti-DENV IgG seroconversion, and probable when diagnosed by single anti-DENV IgM or high titer anti-DENV IgG detection. Severe dengue was defined as evidence of clinically significant plasma leakage or bleeding, organ failure, or shock, according to the 2009 WHO guidance. Complicated dengue was defined as either severe dengue or dengue with presence of any warning sign. Analyses were descriptive.
  
  Results
  
  This analysis included 5,958 travelers with confirmed (n=4,859; 81.6%) or probable (n=1,099; 18.4%) dengue. The median age was 33 years (range: <1–91); 3,007 (50.5%) travelers were female. The median travel duration was 21 days (interquartile range [IQR]: 15–32). The median time between illness onset and GeoSentinel site visit was 7 days (IQR: 4–15). The most frequent reasons for travel were tourism (67.3%), visiting friends or relatives (12.2%), and business (11.0%). The most frequent regions of acquisition were Southeast Asia (50.4%), South-Central Asia (14.9%), the Caribbean (10.9%), and South America (9.2%). Ninety-five (1.6%) travelers had complicated dengue, of whom 27 (0.5%) had severe dengue, and one died. Of 2,710 travelers with data available, 724 (26.7%) were hospitalized. The largest number of cases (n=835) was reported in 2019.
  
  Conclusions
  
  A broad range of international travelers should be aware of the risk of acquiring dengue and receive appropriate pretravel counselling regarding preventive measures. Prospective cohort studies are needed to further elucidate dengue risk by destination and over time, as well as severe outcomes and prolonged morbidity (long-dengue) due to travel-related dengue.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Dengue Dengue Virus Female Humans Infant Male Middle Aged Sentinel Surveillance Travel Travel-Related Illness Young Adult

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• Source:
  J Travel Med. 31(7)
• Document Type:
  Journal Article
• Volume:
  31
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3475f6130e3e9ccabeb8b79a0591c0a3e67b937bb7ed42236ad02a106611bf87580176cf0ab0721a81b4baea8e76d50aea63d9d65e8e7e5e0641803ce1ba8ffb
• Download URL:
  https://stacks.cdc.gov/view/cdc/168533/cdc_168533_DS1.pdf
• File Type:
  [PDF - 146.04 KB ]