CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Epidemiology of Travel-Associated Dengue from 2007 to 2022: A GeoSentinel Analysis
-
10 19 2024
-
-
Source: J Travel Med. 31(7)
[PDF-146.04 KB]
Details:
-
Alternative Title:J Travel Med
-
Personal Author:
-
Corporate Authors:
-
Description:Background
Dengue is a leading cause of febrile illness among international travelers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travelers evaluated at GeoSentinel sites from 2007–2022.
Methods
We retrieved GeoSentinel records of dengue among travelers residing in non-endemic countries. We considered dengue confirmed when diagnosed by a positive DENV-specific RT-PCR, positive NS-1 antigen, and/or anti-DENV IgG seroconversion, and probable when diagnosed by single anti-DENV IgM or high titer anti-DENV IgG detection. Severe dengue was defined as evidence of clinically significant plasma leakage or bleeding, organ failure, or shock, according to the 2009 WHO guidance. Complicated dengue was defined as either severe dengue or dengue with presence of any warning sign. Analyses were descriptive.
Results
This analysis included 5,958 travelers with confirmed (n=4,859; 81.6%) or probable (n=1,099; 18.4%) dengue. The median age was 33 years (range: <1–91); 3,007 (50.5%) travelers were female. The median travel duration was 21 days (interquartile range [IQR]: 15–32). The median time between illness onset and GeoSentinel site visit was 7 days (IQR: 4–15). The most frequent reasons for travel were tourism (67.3%), visiting friends or relatives (12.2%), and business (11.0%). The most frequent regions of acquisition were Southeast Asia (50.4%), South-Central Asia (14.9%), the Caribbean (10.9%), and South America (9.2%). Ninety-five (1.6%) travelers had complicated dengue, of whom 27 (0.5%) had severe dengue, and one died. Of 2,710 travelers with data available, 724 (26.7%) were hospitalized. The largest number of cases (n=835) was reported in 2019.
Conclusions
A broad range of international travelers should be aware of the risk of acquiring dengue and receive appropriate pretravel counselling regarding preventive measures. Prospective cohort studies are needed to further elucidate dengue risk by destination and over time, as well as severe outcomes and prolonged morbidity (long-dengue) due to travel-related dengue.
-
Subjects:
-
Source:
-
Document Type:
-
Volume:31
-
Issue:7
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
