Cluster analysis of World Trade Center (WTC) related lower airway diseases (LAD)

de la Hoz, Rafael E.; Jeon, Yunho; Doucette, John T.; Reeves, Anthony P.; Estépar, Raúl San José; Celedón, Juan C.

doi:10.1097/JOM.0000000000003023

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Cluster analysis of World Trade Center (WTC) related lower airway diseases (LAD)

2 01 2024
By de la Hoz, Rafael E. ; Jeon, Yunho ; Doucette, John T. ; ...
Source: J Occup Environ Med. 66(2):179-184

Public Access Version Available on: February 01, 2025, 12:00 AM

Please check back on the date listed above.

English

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Alternative Title:

J Occup Environ Med
Personal Author:

de la Hoz, Rafael E. ; Jeon, Yunho ; Doucette, John T. ; Reeves, Anthony P. ; Estépar, Raúl San José ; ... More +

de la Hoz, Rafael E. ; Jeon, Yunho ; Doucette, John T. ; Reeves, Anthony P. ; Estépar, Raúl San José ; Celedón, Juan C. Less -
Description:

Introduction:

Cluster analysis can classify without a priori assumptions the heterogeneous chronic lower airway diseases (LAD) found in former workers at the World Trade Center (WTC) disaster site.

Methods:

We selected the first available chest CT scan with quantitative CT (QCT) measurements on 311 former WTC workers with complete clinical, and spirometric data from their closest surveillance visit. We performed a non-hierarchical iterative algorithm K-prototype cluster analysis, using gap measure.

Results:

A 5-cluster solution was most satisfactory. Cluster 5 had the healthiest individuals. In cluster 4 smoking was most prevalent and intense but there was scant evidence of respiratory disease. Cluster 3 had symptomatic subjects with reduced forced vital capacity impairment (low FVC). Clusters 1 and 2 had less dyspneic subjects, but more functional and QCT evidence of chronic obstructive pulmonary disease (COPD) in cluster 1, or low FVC in cluster 2. Clusters 1 and 4 had the highest proportion of rapid FEV1 decliners.

Conclusion:

Cluster analysis confirms low FVC and COPD/pre-COPD as distinctive chronic LAD phenotypes on long term surveillance of the WTC workers.
Subjects:

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Cluster Analysis Forced Expiratory Volume Humans Lung Lung Diseases Pulmonary Disease, Chronic Obstructive Respiration Disorders
Keywords:

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Chronic Obstructive Pulmonary Disease Longitudinal Changes In Lung Function Occupational Lung Disease Smoke Inhalation Injury Spirometry World Trade Center Attack, 2001
Source:

J Occup Environ Med. 66(2):179-184
Pubmed ID:

38305727
Pubmed Central ID:

PMC10842254
Document Type:

Journal Article
Funding:

U01 OH010401/OH/NIOSH CDC HHSUnited States/
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha-512:a3ef0cda9d3ec687097a8f7afc5a685633387c998cf5e6f5365afdf5cc0044ed7ac6b8a3f9e185c036895cc75615dde761e2003652652cb98a0a98c7f2b21fbc
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