Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Kainer, Marion A.; Devasia, Rose A.; Jones, Timothy F.; Simmons, Bryan P.; Melton, Kelley; Chow, Susan; Broyles, Joyce; Moore, Kelly L.; Craig, Allen S.; Schaffner, William

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Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Published Date:

Jul 2007

Source:

Emerg Infect Dis. 13(7):1024-1030.

[PDF - 227.89 KB]

Details:

Personal Authors:

Kainer, Marion A. ; Devasia, Rose A. ; Jones, Timothy F. ; Simmons, Bryan P. ; Melton, Kelley ; ... More ▼

Keywords:

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Description:

Linezolid was approved in 2000 for treatment of gram-positive coccal infections. We performed a case-control study during a hospital outbreak of linezolid-resistant enterococci (LRE) infections, comparing cases of LRE infection (cases) with linezolid-sensitive enterococci infections (controls). Nasal and perirectal swab samples were obtained from all patients in a 1-day point-prevalence survey. We examined antimicrobial drug use and calculated the defined daily dose of linezolid per 1,000 patient-days. Fifteen LRE cases were identified (13 Enterococcus faecalis and 2 E. faecium); 7 were vancomycin-resistant. Compared with controls, case-patients had increased in-hospital mortality rates and lengths of stay. Multivariate analysis identified independent predictors of LRE infection: prior cultures positive for methicillin-resistant Staphylococcus aureus (adjusted odds ratio [AOR] 27), hospitalization duration before index culture (AOR 1.1 per day), and duration of preceding linezolid therapy (AOR 1.1 per day). Linezolid exposure and patient-to-patient transmission appear to be responsible for LRE infections, an important emeraina hospital problem.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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