Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Kainer, Marion A. ; Devasia, Rose A. ; Jones, Timothy F. ; Simmons, Bryan P. ; Melton, Kelley ; ... More +
Kainer, Marion A. ; Devasia, Rose A. ; Jones, Timothy F. ; Simmons, Bryan P. ; Melton, Kelley ; Chow, Susan ; Broyles, Joyce ; Moore, Kelly L. ; Craig, Allen S. ; Schaffner, William Less -
Description:
Linezolid was approved in 2000 for treatment of gram-positive coccal infections. We performed a case-control study during a hospital outbreak of linezolid-resistant enterococci (LRE) infections, comparing cases of LRE infection (cases) with linezolid-sensitive enterococci infections (controls). Nasal and perirectal swab samples were obtained from all patients in a 1-day point-prevalence survey. We examined antimicrobial drug use and calculated the defined daily dose of linezolid per 1,000 patient-days. Fifteen LRE cases were identified (13 Enterococcus faecalis and 2 E. faecium); 7 were vancomycin-resistant. Compared with controls, case-patients had increased in-hospital mortality rates and lengths of stay. Multivariate analysis identified independent predictors of LRE infection: prior cultures positive for methicillin-resistant Staphylococcus aureus (adjusted odds ratio [AOR] 27), hospitalization duration before index culture (AOR 1.1 per day), and duration of preceding linezolid therapy (AOR 1.1 per day). Linezolid exposure and patient-to-patient transmission appear to be responsible for LRE infections, an important emeraina hospital problem.
Subject:
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Acetamides
Anti-Infective Agents
Antimicrobial Agents
Bacterial
Case-Control Studies
Colony Count, Microbial
Communicable Diseases, Emerging
Cross Infection
Disease Outbreaks
Disease Transmission
Drug Resistance
Drug Resistance, Bacterial
Drug Utilization Review
Enterococcus
Enterococcus Faecalis
Enterococcus Faecium
Gram-Positive Bacterial Infections
Horizontal
Hospital Mortality
Humans
Length Of Stay
Methicillin Resistance
Microbial Sensitivity Tests
Multivariate Analysis
Oxazolidinones
Research
Staphylococcus Aureus
Vancomycin Resistance

Source:
Emerg Infect Dis. 13(7):1024-1030.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:0600246025c05ec09f3dcba1ab6ad4147c419162f6834c3f403721be3806e81b
File Type:

Supporting Files

• 	07-0019_appT-s1.pdf	pdf
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