Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Kainer, Marion A.; Devasia, Rose A.; Jones, Timothy F.; Simmons, Bryan P.; Melton, Kelley; Chow, Susan; Broyles, Joyce; Moore, Kelly L.; Craig, Allen S.; Schaffner, William

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Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Supporting Files Public Domain

Jul 2007
By Kainer, Marion A. ; Devasia, Rose A. ; Jones, Timothy F.

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Kainer, Marion A. ; Devasia, Rose A. ; Jones, Timothy F. ; Simmons, Bryan P. ; Melton, Kelley ; Chow, Susan ; Broyles, Joyce ; Moore, Kelly L. ; Craig, Allen S. ; Schaffner, William
Description:

Linezolid was approved in 2000 for treatment of gram-positive coccal infections. We performed a case-control study during a hospital outbreak of linezolid-resistant enterococci (LRE) infections, comparing cases of LRE infection (cases) with linezolid-sensitive enterococci infections (controls). Nasal and perirectal swab samples were obtained from all patients in a 1-day point-prevalence survey. We examined antimicrobial drug use and calculated the defined daily dose of linezolid per 1,000 patient-days. Fifteen LRE cases were identified (13 Enterococcus faecalis and 2 E. faecium); 7 were vancomycin-resistant. Compared with controls, case-patients had increased in-hospital mortality rates and lengths of stay. Multivariate analysis identified independent predictors of LRE infection: prior cultures positive for methicillin-resistant Staphylococcus aureus (adjusted odds ratio AOR 27), hospitalization duration before index culture (AOR 1.1 per day), and duration of preceding linezolid therapy (AOR 1.1 per day). Linezolid exposure and patient-to-patient transmission appear to be responsible for LRE infections, an important emeraina hospital problem.
Subjects:
Source:

Emerg Infect Dis. 13(7):1024-1030.
Document Type:

Journal Article
Volume:

13
Issue:

7
Download URL:

https://stacks.cdc.gov/view/cdc/16669/cdc_16669_DS1.pdf
File Type:

[PDF - 227.89 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:0600246025c05ec09f3dcba1ab6ad4147c419162f6834c3f403721be3806e81b

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