Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Kainer, Marion A.; Devasia, Rose A.; Jones, Timothy F.; Simmons, Bryan P.; Melton, Kelley; Chow, Susan; Broyles, Joyce; Moore, Kelly L.; Craig, Allen S.; Schaffner, William

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Published Date:

Jul 2007

Source:

Emerg Infect Dis. 13(7):1024-1030.

[PDF-227.89 KB]

Details:

Personal Authors:

Kainer, Marion A. ; Devasia, Rose A. ; Jones, Timothy F. ; Simmons, Bryan P. ; Melton, Kelley ; ... More ▼

Keywords:

[+]

Description:

Linezolid was approved in 2000 for treatment of gram-positive coccal infections. We performed a case-control study during a hospital outbreak of linezolid-resistant enterococci (LRE) infections, comparing cases of LRE infection (cases) with linezolid-sensitive enterococci infections (controls). Nasal and perirectal swab samples were obtained from all patients in a 1-day point-prevalence survey. We examined antimicrobial drug use and calculated the defined daily dose of linezolid per 1,000 patient-days. Fifteen LRE cases were identified (13 Enterococcus faecalis and 2 E. faecium); 7 were vancomycin-resistant. Compared with controls, case-patients had increased in-hospital mortality rates and lengths of stay. Multivariate analysis identified independent predictors of LRE infection: prior cultures positive for methicillin-resistant Staphylococcus aureus (adjusted odds ratio [AOR] 27), hospitalization duration before index culture (AOR 1.1 per day), and duration of preceding linezolid therapy (AOR 1.1 per day). Linezolid exposure and patient-to-patient transmission appear to be responsible for LRE infections, an important emeraina hospital problem.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

	07-0019_appT-s1.pdf	application/pdf
	07-0019_finalR.nxml	text/plain
	license.txt	text/plain
	07-0019-F1.gif	image/gif
	07-0019-F1.jpg	image/jpeg
	07-0019-F2.gif	image/gif
	07-0019-F2.jpg	image/jpeg
	07-0019-F3.gif	image/gif
	07-0019-F3.jpg	image/jpeg
	07-0019-F4.gif	image/gif
	07-0019-F4.jpg	image/jpeg

No Related Documents.

You May Also Like:

First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia

Personal Author:

Panesso, Diana; Ospina, Sigifredo; Robledo, Jaime; Vela, María Claudia; Peña, Julieta; Hernández, Orville; Reyes, Jinnethe; Arias, César A.;

Published:

Sep 2002

Source:

Emerg Infect Dis. 8(9):961-965.

Description:

From August 1998 to October 1999, glycopeptide-resistant enterococci (GRE) were isolated from 23 infected patients at a teaching hospital in Medellín, Colombia. Identification at the species level and by multiplex polymerase chain reaction assay ind...

File Type:

[PDF - 353.90 KB]
Linezolid-Resistant Staphylococcus epidermidis, Portugal, 2012

Personal Author:

Barros, Mariana; Branquinho, Raquel; Grosso, Filipa; Peixe, Luísa; Novais, Carla;

Published:

May 2014

Source:

Emerg Infect Dis. 20(5):903-905.

File Type:

[PDF - 318.70 KB]
Falciparum Malaria in Patient 9 Years after Leaving Malaria-Endemic Area

Personal Author:

Theunissen, Caroline; Janssens, Peter; Demulder, Anne; Nouboussié, Denis; Van Esbroeck, Marjan; Van Gompel, Alfons; Van den Ende, Jef;

Published:

Jan 2009

Source:

Emerg Infect Dis. 15(1):115-116.

File Type:

[PDF - 113.22 KB]
De Novo Daptomycin-Nonsusceptible Enterococcal Infections

Personal Author:

Kelesidis, Theodoros; Humphries, Romney; Uslan, Daniel Z.; Pegues, David;

Published:

Apr 2012

Source:

Emerg Infect Dis. 18(4):674-676.

Description:

Potential emergence of enterococcal daptomycin nonsusceptibility among patients with no prior exposure to daptomycin poses clinical and public health challenges. We found that development of infections with daptomycin-nonsusceptible enterococci in th...

File Type:

[PDF - 165.20 KB]
Linezolid-Resistant Staphylococcus cohnii, Greece

Personal Author:

Petinaki, Efi; Kanellopoulou, Maria; Damani, Anthi; Foka, Antigoni; Spiliopoulou, Iris; Skalmoutsou, Nikoletta; Raitsiou, Bogdan; Valakis, Konstantinos; Papafragas, Evangelos;

Published:

Jan 2009

Source:

Emerg Infect Dis. 15(1):116-118.

File Type:

[PDF - 147.44 KB]