Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  N’Guessan, Raphael ; Corbel, Vincent ; Akogbéto, Martin ; Rowland, Mark
• Description:
  The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated nets (ITN) and indoor residual spraying (IRS) was undertaken in experimental huts at 2 sites in Benin, the first where kdr is present at high frequency (Ladji), the second-where An. gambiae is susceptible (Malanville). Holes were made in the nets to mimic worn nets. At Malanville, 96% of susceptible An. gambiae were inhibited from blood-feeding, whereas at Ladji feeding was uninhibited by ITNs. The mortality rate of An. gambiae in ITN huts was 98% in Malanville but only 30% at Ladji. The efficacy of IRS was equally compromised. Mosquitoes at Ladji had higher oxidase and esterase activity than in a laboratory-susceptible strain, but this fact did not seem to contribute to resistance. Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin.
• Subjects:
  Animals Anopheles Gambiae Bedding And Linens Culex Humans Indoor Residual Spraying Insecticide Resistance Insecticides Insecticide Treated Net Malaria Mosquito Control Nitriles Pyrethrins Pyrethroid Resistance Research

  More +
• Source:
  Emerg Infect Dis. 13(2):199-206.
• Document Type:
  Journal Article
• Place as Subject:
  Benin
• Location:
  Africa
• Volume:
  13
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c217257c2d98e3690af72909debd54169fea4a519a205ed4af0bf14a1aacc7e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/16390/cdc_16390_DS1.pdf
• File Type:
  [PDF - 163.36 KB ]