Profiling Metal-Induced Genotoxic Endpoints

Shoeb, Mohammad; Zarus, Gregory M.; Abadin, Henry E.

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Profiling Metal-Induced Genotoxic Endpoints

12-2023
By Shoeb, Mohammad ; Zarus, Gregory M. ; Abadin, Henry E.
Source: J Environ Health. 86(5):30-35

[PDF-587.16 KB]

English

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Details:

Alternative Title:

J Environ Health
Personal Author:

Shoeb, Mohammad ; Zarus, Gregory M. ; Abadin, Henry E.

Shoeb, Mohammad ; Zarus, Gregory M. ; Abadin, Henry E. Less -
Description:

Many toxic metals are involved in the initiation and progression of DNA damage that can result in the activation of DNA damage response machinery at double- and single-stranded DNA; this response can result in global and gene-specific DNA alteration. The toxicological profiles from the Agency for Toxic Substances and Disease Registry (ATSDR) and several other studies have demonstrated the influence of metal exposure-induced genotoxic endpoints and epigenetic modifications. Our review systematically summarizes accumulating evidence from ATSDR toxicological profiles and the available literature that demonstrate a possible induction of various genotoxic endpoints and metal exposures. We include in this article studies on chromium, arsenic, nickel, lead, mercury, and zinc.
Source:

J Environ Health. 86(5):30-35
Pubmed ID:

39239121
Pubmed Central ID:

PMC11375607
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

86
Issue:

5
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:3ed00d7430b6d874cbaa3be0588452e954ecdf9e02f6707697853e0412ae792a8d136cce17bce145bcb8838bf82f69c995d3995fafcb28af16df05783f56d9cd
Download URL:

https://stacks.cdc.gov/view/cdc/162225/cdc_162225_DS1.pdf
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