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Profiling Metal-Induced Genotoxic Endpoints

Supporting Files
File Language:
English


Details

  • Alternative Title:
    J Environ Health
  • Personal Author:
  • Description:
    Many toxic metals are involved in the initiation and progression of DNA damage that can result in the activation of DNA damage response machinery at double- and single-stranded DNA; this response can result in global and gene-specific DNA alteration. The toxicological profiles from the Agency for Toxic Substances and Disease Registry (ATSDR) and several other studies have demonstrated the influence of metal exposure-induced genotoxic endpoints and epigenetic modifications. Our review systematically summarizes accumulating evidence from ATSDR toxicological profiles and the available literature that demonstrate a possible induction of various genotoxic endpoints and metal exposures. We include in this article studies on chromium, arsenic, nickel, lead, mercury, and zinc.
  • Source:
    J Environ Health. 86(5):30-35
  • Pubmed ID:
    39239121
  • Pubmed Central ID:
    PMC11375607
  • Document Type:
    Journal Article
  • Funding:
    CC999999/ImCDC/Intramural CDC HHSUnited States/
  • Volume:
    86
  • Issue:
    5
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:3ed00d7430b6d874cbaa3be0588452e954ecdf9e02f6707697853e0412ae792a8d136cce17bce145bcb8838bf82f69c995d3995fafcb28af16df05783f56d9cd
  • Download URL:
  • File Type:
    Filetype[PDF - 587.16 KB ]
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