Pilot Study of Maternal Autoantibody Related Autism (MAR ASD)

Details

• Alternative Title:
  J Dev Behav Pediatr
• Personal Author:
  Angkustsiri, Kathleen ; Fussell, Jill J. ; Bennett, Amanda ; Schauer, Joseph ; Ramirez-Celis, Alexandra ; Hansen, Robin L. ; Van de Water, Judy
• Description:
  Objective:
  
  To investigate the presence of Maternal Autoantibody-Related Autism Spectrum Disorder (MAR ASD) in 2 geographically distinct DBPNet clinical sites (Pennsylvania and Arkansas). MAR ASD is a biologically defined subtype of autism spectrum disorder that is defined by the presence of autoantibodies specific to proteins in the fetal brain and present in approximately 20% of a Northern California sample but has not been studied in other states.
  
  Methods:
  
  Sixty-eight mothers of children with ASD were recruited from 2 DBPNet clinics and provided blood samples. Mothers also completed behavioral questionnaires about their children, and data from the child’s clinical diagnostic assessment was abstracted.
  
  Results:
  
  Mean age of mothers was 38.5±6.1 years, and mean age of children was 8.3±2.7 years. MAR ASD was present in 24% of the sample and similar across sites. Children of +MAR mothers had more severe autism symptoms as measured by ADOS comparison scores (W=3604, p<0.001) and the Social Communication Questionnaire (W=4556; p<0.001). There were no differences in IQ, adaptive function, or aberrant behavior.
  
  Conclusion:
  
  MAR ASD is a subtype of autism that is present in similar frequencies across 3 states and related to autism severity.
  
  
• Subjects:
  Adult Autism Spectrum Disorder Autistic Disorder Autoantibodies Child Child, Preschool Female Humans Mothers Pilot Projects
• Keywords:
  Anti-fetal Brain Autoantibodies Autism Immune Maternal Autoantibodies Pre- And Peri-natal Risk Factors
• Source:
  J Dev Behav Pediatr. 43(8):465-471
• Pubmed ID:
  35943360
• Pubmed Central ID:
  PMC9561005
• Document Type:
  Journal Article
• Funding:
  R01 ES015359/ES/NIEHS NIH HHSUnited States/ ; U54 HD079125/HD/NICHD NIH HHSUnited States/ ; P30 ES023513/ES/NIEHS NIH HHSUnited States/ ; P50 HD103526/HD/NICHD NIH HHSUnited States/ ; P01 ES011269/ES/NIEHS NIH HHSUnited States/ ; UR3 DD000823/DD/NCBDD CDC HHSUnited States/
• Volume:
  43
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c2dd1257673e27933036067242d52349268c40047e46c27c252513b5fde15e480f4c98d2f3228f04d5921de5ea998d09e96f75e93fe70c083a544d0739e31168
• Download URL:
  https://stacks.cdc.gov/view/cdc/162082/cdc_162082_DS1.pdf
• File Type:
  [PDF - 200.97 KB ]