Host Range Restriction and Pathogenicity in the Context of Influenza Pandemic

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Neumann, Gabriele ; Kawaoka, Yoshihiro
• Description:
  Influenza A viruses cause pandemics at random intervals. Pandemics are caused by viruses that contain a hemagglutinin (HA) surface glycoprotein to which human populations are immunologically naive. Such an HA can be introduced into the human population through reassortment between human and avian virus strains or through the direct transfer of an avian influenza virus to humans. The factors that determine the interspecies transmission and pathogenicity of influenza viruses are still poorly understood; however, the HA protein plays an important role in overcoming the interspecies barrier and in virulence in avian influenza viruses. Recently, the RNA polymerase (PB2) protein has also been recognized as a critical factor in host range restriction, while the nonstructural (NS1) protein affects the initial host immune responses. We summarize current knowledge of viral factors that determine host range restriction and pathogenicity of influenza A viruses.
• Subjects:
  Amino Acid Sequence Animals Birds Disease Outbreaks HA Hemagglutinins Host Range Humans Influenza, Human Influenza A Virus Influenza In Birds Molecular Sequence Data NA Neuraminidase Pathogenesis PB2 Perspective Reassortant Viruses Viral Nonstructural Proteins Viral Proteins

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• Source:
  Emerg Infect Dis. 12(6):881-886.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:749887912bfa01e482ddfa9cf7e68a82defe9dc951d577d70a81ceb76c595439
• Download URL:
  https://stacks.cdc.gov/view/cdc/16119/cdc_16119_DS1.pdf
• File Type:
  [PDF - 148.71 KB ]