Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Neumann, Gabriele ; Kawaoka, Yoshihiro
Neumann, Gabriele ; Kawaoka, Yoshihiro Less -
Description:
Influenza A viruses cause pandemics at random intervals. Pandemics are caused by viruses that contain a hemagglutinin (HA) surface glycoprotein to which human populations are immunologically naive. Such an HA can be introduced into the human population through reassortment between human and avian virus strains or through the direct transfer of an avian influenza virus to humans. The factors that determine the interspecies transmission and pathogenicity of influenza viruses are still poorly understood; however, the HA protein plays an important role in overcoming the interspecies barrier and in virulence in avian influenza viruses. Recently, the RNA polymerase (PB2) protein has also been recognized as a critical factor in host range restriction, while the nonstructural (NS1) protein affects the initial host immune responses. We summarize current knowledge of viral factors that determine host range restriction and pathogenicity of influenza A viruses.
Subject:
[+]
Amino Acid Sequence
Animals
Birds
Disease Outbreaks
HA
Hemagglutinins
Host Range
Humans
Influenza, Human
Influenza A Virus
Influenza In Birds
Molecular Sequence Data
NA
Neuraminidase
Pathogenesis
PB2
Perspective
Reassortant Viruses
Viral Nonstructural Proteins
Viral Proteins

Source:
Emerg Infect Dis. 12(6):881-886.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:749887912bfa01e482ddfa9cf7e68a82defe9dc951d577d70a81ceb76c595439
File Type:

Supporting Files

• 	05-1336.nxml	txt
  	license.txt	txt

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